How bacterial pathogens colonize their hosts and invade deeper tissues.

By D. Ribet, P. Cossart. Microbes and infection, 2015

679 citations recorded by the source corpus.

Bacterial pathogens have evolved a wide range of strategies to colonize and invade human organs, despite the presence of multiple host defense mechanisms. In this review, we will describe how pathogenic bacteria can adhere and multiply at the surface of host cells, how some bacteria can enter and proliferate inside these cells, and finally how pathogens may cross epithelial or endothelial host barriers and get access to internal tissues, leading to severe diseases in humans.

Subfields: Endocrinology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/55a71a1e7547cacc76d04bcfe9f113d3812e7ae7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Edison Ong
2. Mei U. Wong
3. Anthony Huffman
4. F. J. Ruiz-Ojeda
5. J. Plaza-Díaz
6. M. Gil-Campos
7. Á. Gil
8. Yongqun Oliver He

Citations in the corpus

• Mechanisms of Action of Probiotics. (2019, background): “These adhesins recognize various classes of host molecules including transmembrane proteins such as integrins or cadherins, or components of the extracellular matrix such as collagen, fibronectin, laminin, or elastin (35).”
• COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning (2020, background): “Adhesin plays a critical role in the virus adhering to the host cell and facilitating the virus entry to the host cell (38), which has a significant association with the vaccineinduced protection (39).”