Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.

By A. Fasano. Physiological Reviews, 2011

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Commensal Clostridia: leading players in the maintenance of gut homeostasis (2013, background): “Dysregulation of any of the aforementioned components have been implicated, not only in the pathogenesis of IBD, but in many other GI disorders, including infectious enterocolitis, IBS, small intestinal bowel overgrowth, celiac sprue, hepatic fibrosis, atopic manifestations and food intolerance [34-”
Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “…Clinical and preclinical Grootjans et al., 2010 CIRCULATING MARKERS Zonulin Plasma Small intestine epithelial cell damage Clinical and preclinical Fasano, 2011 Intestinal fatty acid binding protein (I-FABP) Plasma Small intestine permeability Clinical and preclinical Derikx et al.,…”
Spectrum of gluten-related disorders: consensus on new nomenclature and classification (2012, background): “When the integrity of the intestinal tj is compromised, an immune response to environmental antigens that cross-react with host antigens may develop, thereby triggering the onset of CD [60,61].”
The intestinal barrier: a fundamental role in health and disease (2017, background): “In normal conditions, transport of the toxic gliadin fraction of gluten to the lamina propria is limited [34,105,106].”