Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome.

By M. Gobert, I. Treilleux, N. Bendriss-Vermare, T. Bachelot, Sophie Goddard-Léon, V. Arfi, C. Biota, A. Doffin, I. Durand, D. Olive and 8 more. Cancer Research, 2009

727 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7926549d0cf1f54b7cd258401fca9cac62efa7f3

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In Immunology

Citations in the corpus

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. (2013, background): “FOXP3 cells surrounding neoplastic lesions appear to be particularly active, and their abundance predicts disease relapse better than that of FOXP3 cells infiltrating the tumor bed (Gobert et al., 2009).”
Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment (2014, background): “An increased number of regulatory T cells are commonly found in various tumors [91–94].”
The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis (2011, background): “…Kawai et al , 2008; Perrone et al , 2008; Sasaki et al , 2008; Shah et al , 2008; Tomsova et al , 2008; Adams et al , 2009; De Jong et al , 2009; Gobert et al , 2009; Jensen et al , 2009; Leffers et al , 2009; Milne et al , 2009; Ruffini et al , 2009; Stumpf et al , 2009; Al Attar et al , 2010;…”
VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer. (2013, background): “human, 2 studies have shown an increased proportion of dividing Tregs in tumors or peripheral blood in patients with breast cancer and acute myeloid leukemia (44, 45).”
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. (2015, background): “The presence of CD4 regulatory T cells (Treg) has been associated with both good and bad [10, 11, 12].”
Regulatory T cells exhibit distinct features in human breast cancer (2016, neutral): “The presence of Treg cells in the tumor microenvironment has recently emerged as a characteristic feature of human tumors including breast carcinomas (Gobert et al., 2009; Hossain et al., 2013; Senovilla et al., 2012; Shang et al., 2015).”
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. (2013, positive): “In BC, the majority of studies investigating CD4 + TIL have been focused on Tregs (68), with their increased presence linked with a poor prognosis in ER + disease (21, 69) but a good clinical outcome in ER – disease (70).”
The immune contexture in human tumours: impact on clinical outcome (2012, positive): “Indeed, several reports support this concept, and the high infiltration of T Reg cells has been correlated with poor overall survival in breast cance”
Immune Cell Abundance and T-cell Receptor Landscapes Suggest New Patient Stratification Strategies in Head and Neck Squamous Cell Carcinoma (2023, unknown): “Composed of multiple immune cell types such as T cells, B cells, mature DCs, as well as differentiated stromal cells and endothelial cells (17), TLSs have been described to be particularly rich in PCs (42–45) and are often found in associa-tionwithCD8 + Tcells(46–48)andregulatoryTcells(49–51).”