The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis
By Marloes J. M. Gooden, De Bock, N. Leffers, T. Daemen, H. Nijman. British Journal of Cancer, 2011
1,208 citations recorded by the source corpus.
Background:Tumour-infiltrating lymphocytes (TILs) are often found in tumours, presumably reflecting an immune response against the tumour. We carried out a systematic review and meta-analysis, aiming to establish pooled estimates for survival outcomes based on the presence of TILs in cancer.Methods:A Pubmed and Embase literature search was designed. Studies were included, in which the prognostic significance of intratumoural CD3+, CD4+, CD8+, and FoxP3+ lymphocytes, as well as ratios between these subsets, were determined in solid tumours.Results:In pooled analysis, CD3+ TILs had a positive effect on survival with a hazard ratio (HR) of 0.58 (95% confidence interval (CI) 0.43–0.78) for death, as did CD8+ TILs with a HR of 0.71 (95% CI 0.62–0.82). FoxP3+ regulatory TILs were not linked to overall survival, with a HR of 1.19 (95% CI 0.84–1.67). The CD8/FoxP3 ratio produced a more impressive HR (risk of death: HR 0.48, 95% CI 0.34–0.68), but was used in relatively few studies. Sample size and follow-up time seemed to influence study outcomes.Conclusion:Any future studies should be carefully designed, to prevent overestimating the effect of TILs on prognosis. In this context, ratios between TIL subsets may be more informative.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/28f4c2cd1c282200c466af4b52097f22c0704f72
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In Immunology
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Citations in the corpus
- The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses (2020, background): “It is corroborated that a high level of CD3, CD4, and CD8 TILs is associated with improved overall survival rates in cancer patients (17) while high levels”
- Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. (2014, neutral): “(%) Overall survival 79 (79) 33 432 (82) (33,34,39,41–46,48–50,53,54,59,61–70,73,74,76–81,83,84, 86,89,90,92–112,114–120,122–128,130–135) Cancer-specific survival 10 (10) 14 407 (36) (40,52,57,75,78,91,94,113,115,130) Progression-free survival 16 (16) 7822 (19) (34,45,47,49,61,65,67,71,77,101,108,11”
- Cooperation between Constitutive and Inducible Chemokines Enables T-cell Engraftment and Immune Attack in Solid Tumors (2019, background): “, 2006), and most other solid tumor types (Fridman et al., 2012; Gooden et al., 2011).”