The immune contexture in human tumours: impact on clinical outcome

By W. Fridman, Franck Pagès, C. Sautès-Fridman, Jérôme Galon. Nature Reviews. Cancer, 2012

4,576 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7111d0ae2766f7c3c30118a877991b8fa45b05cf

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Citations in the corpus

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints (2014, neutral): “For some cancer types, it is becoming clear that simple quantitation of lymphocyte infiltration has prognostic significance, suggesting that lymphocyte infiltration is not passive but may actively promote or inhibit tumor growth (1).”
Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic (2018, background): “The presence of tumor-infiltrating lymphocytes (TILs) might confer a prognostic and a predictive impact [24, 25].”
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images (2018, neutral): “Recent studies further suggest that the importance of spatial context and the nature of cellular heterogeneity of the tumor microenvironment, in terms of the immune inﬁltrate involving the tumor center and/or invasive margin, can also correlate with cancer prognosis (Fridman et al., 2012).”
Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours (2013, background): “Over the past few years, the area of immune regulation at the level of the tumour microenvironment has gained a forefront position in cancer research, in CRC [9,10,30,34,55], melanoma [67] and all other cancer types [7].”
The Two Faces of IL-6 in the Tumor Microenvironment (2014, background): “While the predominant view of IL-6 in cancer is as a key driver of malignancy, there is a second face of IL-6 that has sparked interest due its beneficial role in promoting anti-tumor immunity [49,50].”
Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment (2019, background): “The immune contexture, or the frequency, location and functional orientation of different immune cell subsets, varies substantially between tumor types and also between individuals with seemingly identical cancers (2).”
Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data (2017, background): “…many other tumors, like melanoma or colorectal cancer, display high level of infiltrating immune cells and the role of immune infiltrations on tumor progression and survival appears to be especially important in these tumors (Clemente et al., 1996; Fridman et al., 2012; Galon et al., 2006).”
The tumor microenvironment at a glance (2012, background): “Among these, cytotoxic CD8+ memory T cells (CD8+CD45RO+), which are normally antigen ‘experienced’ and capable of killing tumor cells, are strongly associated with a good prognosis (Fridman et al., 2012).”