NF-kappaB: linking inflammation and immunity to cancer development and progression.

By M. Karin, F. Greten. Nature reviews. Immunology, 2005

1,397 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/78fd11db5041bb72d75031e1fbaf9d251c8626fb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Mechanisms of immune evasion by tumors. (2006, background): “…NFkB activation within infiltrating hematopoietic elements is thought to result in production of various proinflammatory cytokines and chemokines, a number of which enhance proliferative responses among IECs as well as providing an antiapoptotic effect (Greten et al., 2004; Karin and Greten, 2005).”
Immunosuppressive strategies that are mediated by tumor cells. (2007, background): “Mounting evidence supports the idea that immune cells and inflammatory mediators (cytokines, chemokines) within the tumor microenvironment, can either be beneficial or detrimental for tumor progression (80).”
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses (2009, unknown): “Conditional knockout mice have shown the importance of nuclear factor-κB (NF-κB) signaling not only in the epithelial cells that are the target of transformation but also in myeloid cells that contribute to inflammatio”
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. (2013, background): “TNFa and IL-1b are considered two of the most common upstream activators of NF-kB signaling in inflammatory diseases and tumors (Karin and Greten, 2005).”
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. (2008, background): “IL-1b has a strong link to NF-kB, a key regulator of cytokinedependent inflammatory gene expression (Dinarello, 1996; Karin and Greten, 2005).”
Persistently-activated Stat3 maintains constitutive NF-κB activity in tumors (2009, unknown): “In several mouse carcinogen or tissue damageinduced inflammation cancer models, IKK is critical for tumor initiation (Karin and Greten, 2005).”
Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases (2008, unknown): “…diseases, and even psychological diseases (Aggarwal et al., 2006a); (Hansson et al., 2006); (Garodia et al., 2007) (Khanna et al., 2007) (Libby, 2007) (Odrowaz-Sypniewska, 2007) (Robinson et al., 2007) (Selmi et al., 2007) (Packard and Libby, 2008) (Hold and El-Omar, 2008) (Dantzer et al., 2008).”
TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion (2010, background): “Inhibition of TNF-a results in a marked reduction in tumour onset and tumour burden (Karin and Greten, 2005).”
Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression (2007, background): “A growing body of evidence has recently implicated tumor-infiltrating leukocytes as causal players in cancer development [2-8].”