Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases

By Bharat B. Aggarwal, K. Harikumar. International Journal of Biochemistry and Cell Biology, 2008

1,941 citations recorded by the source corpus.

Although safe in most cases, ancient treatments are ignored because neither their active component nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (Curcuma longa), which was identified more than a century ago. For centuries it has been known that turmeric exhibits anti-inflammatory activity, but extensive research performed within the past two decades has shown that the this activity of turmeric is due to curcumin, a diferuloylmethane. This agent has been shown to regulate numerous transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes that have been linked to inflammation. The process of inflammation has been shown to play a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. In the current review, we provide evidence for the potential role of curcumin in the prevention and treatment of various pro-inflammatory chronic diseases. These features, combined with the pharmacological safety and negligible cost, render curcumin an attractive agent to explore further.

Subfields: Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/5339b4f80d0a95099ed13aff1cb09e08c44cecb2

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Citations in the corpus

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma (2011, background): “The anti-inflammatory properties of curcumin have been investigated in a number of disease entities such as Alzheimer’s disease, cardiovascular disease, diabetes, asthma, inflammatory bowel disease, arthritis, pancreatitis and renal disease [74-90].”
Targets of curcumin (2011, background): “Over the last 60 years, more than 3000 studies have demonstrated curcumin has antioxidant, antibacterial, antifungal, antiviral, anti-inflammatory, antiproliferative, proapoptotic and anti-atherosclerotic effects, exerting medicinal benefits against neurodegenerative diseases, arthritis, allergy, in”
Curcumin, an active component of turmeric (Curcuma longa), and its effects on health (2017, background): “It has been shown that piperine increases the bioavailability of curcumin on humans and rats by decreasing glucuronidation of curcumin (Aggarwal and Harikumar, 2009).”
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. (2008, background): “[8] Aggarwal BB, Harikumar KB.”
Design of Curcumin Loaded PLGA Nanoparticles Formulation with Enhanced Cellular Uptake, and Increased Bioactivity in vitro and Superior Bioavailability in vivo (2009, neutral): “Although curcumin is pharmacologically quite safe in human [1,11,41], the efficacy of curcumin (NP) remains to be determined.”
Curcumin: A Review of Its’ Effects on Human Health (2017, background): “It has been shown to benefit inflammatory conditions [9], metabolic syndrome [10], pain [11], and to help in the management of inflammatory and degenerative eye conditions [12,13].”
A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery (2019, background): “This includes acquired immunodeficiency disease (AIDS), inflammatory bowel diseases, neurodegenerative diseases, inflammatory bowel diseases, cancer, cardiovascular diseases, allergies, rheumatoid arthritis, diabetes, psoriasis, scleroderma, asthma and bronchitis, and renal ischemia [74].”