Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.
By S. Tu, G. Bhagat, G. Cui, S. Takaishi, E. Kurt-Jones, B. Rickman, Kelly S. Betz, M. Penz-Oesterreicher, O. Bjorkdahl, J. Fox and 1 more. Cancer Cell, 2008
867 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/137c99c92a78ecf17dddf0a3a455d9128ebed161
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- A. Mantovani
- D. Gabrilovich
- A. Sica
- P. Allavena
- S. Ostrand-Rosenberg
- C. Garlanda
- P. Sinha
- T. Condamine
In Oncology
- A. Mantovani
- A. Sica
- P. Allavena
- D. Gabrilovich
- C. Garlanda
- S. Ostrand-Rosenberg
- P. Sinha
- F. Colotta
Citations in the corpus
- Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “early recruitment of myeloid-derived suppressor cells (MDSCs) [50].”
- Pyroptosis: mechanisms and diseases (2021, background): “Overexpression of IL-1β in the stomach contributed to the development of gastric cancer by increasing the number of MDSCs.(325)”
- Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia (2012, background): “…to induce the accumulation of Gr1+CD11b+ myeloid cells and the concomitant suppression of T cell immune response in a variety of mouse tumor models (Bunt et al., 2007; Melani et al., 2003; 844 Cancer Cell 21, 836–847, June 12, 2012 ª2012 Elsevier Inc. Pilon-Thomas et al., 2011; Tu et al., 2008).”
- Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function (2010, background): “IL-1 receptor signaling inhibited the development of gastric preneoplasia and suppressed MDSC mobilization [61].”
- Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth (2011, positive): “BM-derived cells (BMDCs) are often recruited to carcinogenic sites by cytokines such as IL-1b (Houghton et al., 2004; Tu et al., 2008), and indeed, CAFs promote further cell recruitment through secretion of chemokines such as SDF-1 (Orimo et al., 2005).”
- Immunity, Inflammation, and Cancer (2010, neutral): “, 2008), in which IL-1β is also a tumor promoter (Tu et al., 2008).”
- iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “felis developed gastric adenocarcinomas but at a low incidence (Tu et al., 2008).”
- Tumor-derived granulocyte-macrophage colony stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer (2012, background): “Stomach-specific expression of human IL-1b in transgenic mice leads to spontaneous gastric inflammation, invasive cancer, and mobilization of MDSC (Tu et al., 2008).”