TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
By Y. Wu, BP Zhou. British Journal of Cancer, 2010
718 citations recorded by the source corpus.
Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-κB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.
Subfields: Cancer Research, Oncology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/2911133de46825432cc2daee9f6e66793b1e0b2c
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In Cancer Research
In Oncology
Citations in the corpus
- The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. (2011, background): “In this respect, it is important to note that TNF is one of the key mediators of cancer-related inflammation that drives tumor development and/or progression (Kim et al., 2009; Wu and Zhou, 2010).”
- The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective (2019, background): “(Nieto, 2002; Wu & Zhou, 2010).”