Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression
By D. DeNardo, Lisa M. Coussens. Breast Cancer Research, 2007
691 citations recorded by the source corpus.
Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Moreover, accumulated clinical and experimental data indicate that the outcome of an immune response toward an evolving breast neoplasm is largely determined by the type of immune response elicited. Acute tumor-directed immune responses involving cytolytic T lymphocytes appear to protect against tumor development, whereas immune responses involving chronic activation of humoral immunity, infiltration by Th2 cells, and protumor-polarized innate inflammatory cells result in the promotion of tumor development and disease progression. Herein we review this body of literature and summarize important new findings revealing the paradoxical role of innate and adaptive leukocytes as regulators of breast carcinogenesis.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/031421d230a694735e3f25e51807b36fb8e72ffa
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- L. Emens
- Lisa M. Coussens
- D. DeNardo
- J. Barreto
- D. Tawfik
- Pauline Andreu
- L. Vasquez
- Nikita S. Kolhatkar
In Oncology
Citations in the corpus
- Breast Cancer Immunotherapy: Facts and Hopes (2017, background): “Ultimately, there is a shift from acute to chronic inflammation, establishing a complex tumor microenvironment (TME) consisting of suppressive immune cells [regulatory T cells (Treg), myeloid-derived suppressor cells (MDSC), and B cells] and stromal cells (fibroblasts and endothelial cells) that all”
- CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages (2009, background): “Breast cancer development is characterized by significant increases in the presence of both innate and adaptive immune cells, with B cells, T cells, and macrophages representing the most abundant leukocytes present in neoplastic stroma (DeNardo and Coussens, 2007).”
- Regulatory T cells exhibit distinct features in human breast cancer (2016, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript infiltrating lymphocytes and their subset composition paralleling disease progression suggest that the underlying interactions of these tumors with immune cells are important (DeNardo and Coussens, 2007).”