Current knowledge on exosome biogenesis and release
By N. P. Hessvik, A. Llorente. Cellular and Molecular Life Sciences, 2017
2,093 citations recorded by the source corpus.
Exosomes are nanosized membrane vesicles released by fusion of an organelle of the endocytic pathway, the multivesicular body, with the plasma membrane. This process was discovered more than 30 years ago, and during these years, exosomes have gone from being considered as cellular waste disposal to mediate a novel mechanism of cell-to-cell communication. The exponential interest in exosomes experienced during recent years is due to their important roles in health and disease and to their potential clinical application in therapy and diagnosis. However, important aspects of the biology of exosomes remain unknown. To explore the use of exosomes in the clinic, it is essential that the basic molecular mechanisms behind the transport and function of these vesicles are better understood. We have here summarized what is presently known about how exosomes are formed and released by cells. Moreover, other cellular processes related to exosome biogenesis and release, such as autophagy and lysosomal exocytosis are presented. Finally, methodological aspects related to exosome release studies are discussed.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/454b33061929fc269cf675f37a07f82b95f29929
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Citations in the corpus
- Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19 (2020, positive): “However, bone marrow derived exosomes, a complex mix of signaling nanovesicles secreted by bmMSCs, are a novel, multitargeted, next generation biologic agent that could be the key to downregulating the cytokine storm, and to reversing the suppression of host antiviral defenses that characterize COVI”
- The biology, function, and biomedical applications of exosomes (2020, neutral): “Thetrans-Golginetworkandendoplasmic reticulumcanalsocontributetotheformation andthecontentoftheESE( 2 , 4 – 6 , 13 , 14 ).”
- Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “It begins with the in-budding of endosomes, which in turn forms MVBs that contain intra-luminal vesicles (ILVs) [42,43].”