MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

By Jidong Liu, M. A. Valencia-Sanchez, Gregory J. Hannon, R. Parker. Nature Cell Biology, 2005

1,341 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/787de4c8a5558ddca3a024bbb8025bf0a43a04bd

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Citations in the corpus

RNA silencing: Methods and protocols (2006, positive): “Specific circulating miRNA profiles have previously been described in patients with chronic heart failure (CHF).[5-9] A few studies have examined miRNAs in acute heart failure (AHF).”
P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing (2007, background): “... mRNA decay (NMD), a pathway that degrades mRNAs harboring premature translation termination codons (or nonsense codons) (22, 45, 52); (ii) proteins with roles in AU-rich element (ARE)mediated mRNA decay, a pathway that degrades mRNAs containing AU-rich elements in their 3 untranslated regions (U”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “P-bodies are sites of accumulation of untranslated mRNAs and of multiple enzymes involved in mRNA turnover and translational repression, including Ago proteins and miRNA”
MicroRNAS and their regulatory roles in plants. (2006, background): “This suggests that miRNA binding directs the message to the P body, where it can be sequestered from the translation machinery and destabilized (77, 120).”
General translational repression by activators of mRNA decapping. (2005, background): “ore recently, the demonstration that mRNAs translaionally repressed by miRNAs accumulate in P bodies uggests that miRNA based translational repression ight also interact with this general translation represion machinery (Liu et al., 2005).”
A role for the P-body component GW182 in microRNA function (2005, background): “Recently, Argonaute proteins, which are key RNAi effector components, and their target mRNAs were shown to localize to cytoplasmic foci known as P-bodies or GW-bodie”
Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “…Processing Body Processing (P)-bodies are cytoplasmic ribonucleoprotein aggregates where translationally repressed mRNAs, including miRNA targets, accumulate (Teixeira et al., 2005; Liu et al., 2005), prior to either degradation or reinitiation of translation (reviewed in Eulalio et al., 2007a).”
How do microRNAs regulate gene expression? (2008, background): “The interactions with Dcp1/2 and GW182 still occurred with Ago mutants deficient in RNA binding that did not localize to P-bodies ( 54 , 67), and the interaction with p54 still occurred in cells depleted of Lsm1 (a protein found in P-bodies and implicated in RNA processing), which dispersed the foci”