Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCFFbw7 Ubiquitin Ligase

By D. Koepp, L. Schaefer, Xin Ye, K. Keyomarsi, C. Chu, J. Harper, Stephen J. Elledge. Science, 2001

845 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/787aa984a754733b547b82ba6e2c943121c1b199

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Citations in the corpus

Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex (2006, background): “5C; S1C), which are ubiquitinated by the SCFFBW7 and APC/C complexes respectively (Harper et al., 2002; Koepp et al., 2001).”
Multidimensional proteomics for cell biology (2015, background): “This is shown by the cell cycle-dependent phosphorylation of cyclin E, which can trigger its ubiquitin-depend-ent degradation 53 .”
The SCF ubiquitin ligase: insights into a molecular machine (2004, background): “Cdk2 attenuation is now maintained by SCF Fbw7 -mediated degradation of its necessary partner cyclin E (Ref”
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation (2008, background): “, and it became apparent that Cdc4 might bind these substrates through a conserved phospho-epitope, which was later described as the Cdc4 phospho-degron (CPD”
Systematic analysis and nomenclature of mammalian F-box proteins. (2004, background): “…of mammalian FBXW7 and -TRCP1/2 in both C. elegans and Drosophila. c-MYC and cyclin E are targeted by ago/FBXW7 in both Drosophila and mammals (Koepp et al. 2001; Moberg et al. 2001, 2004; Strohmaier et al. 2001; Tetzlaff et al. 2004; Welcker et al. 2004), and Notch is targeted by…”
Auxin receptors and plant development: a new signaling paradigm. (2008, background): “For example, the mammalian SCF Fbw7 promotes the degradation of a number of growth regulators, including cyclin E, c-Myc, c-Jun, Notch, Presenilin, and sterol regulatory element-binding proteins (SREBP) (Koepp et al. 2001, Minella & Clurman 2005, Nateri et al. 2004, Orlicky et al. 2003, Ye et al. 20”
Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7 (2004, background): “The turnover of cyclin E is also regulated by both Fbw7 (Koepp et al, 2001; Moberg et al, 2001; Strohmaier et al, 2001) and Skp2 (Nakayama et al, 2000).”
TRIM proteins and cancer (2011, background): “Thus, the identification and targeting of E3 ligases that are involved in the regulation of oncoproteins and tumour suppressor proteins is a current focus of cancer researc”