Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7
By M. Yada, S. Hatakeyama, T. Kamura, Masaaki Nishiyama, R. Tsunematsu, Hiroyuki Imaki, N. Ishida, Fumihiko Okumura, Kei-ichi Nakayama, Keiichi I. Nakayama. EMBO Journal, 2004
838 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/8ba1d62b18376b2531fa03f85398f654a26760df
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Yibing Yang
- R. Eisenman
- Maolei Zhang
- Xinya Gao
- B. Clurman
- M. Welcker
- Sheng Yan
- Kun Zhao
Citations in the corpus
- FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation (2008, background): “FBW7 mediates phosphorylation-dependent MYC degradation through an N-terminal degron that is centred on threonine 58 (T58”
- Myc's broad reach. (2008, background): “During the last several years, it has been demonstrated that the proteasome-mediated degradation of c-Myc is directed by at least two ubiquitin ligases—Fbw7, which recognizes the Myc Box I phosphodegron (Welcker et al. 2004a,b; Yada et al. 2004), and Skp2, which interacts with a non-phospho-dependen”
- Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma (2017, background): “3G34R/V it has been reported to play a role in MYC/ MYCN stabilization through its action as a component of the SCF-like ubiquitin ligase complex that targets MYC/MYCN for proteasomal degradation (Welcker et al., 2004; Yada et al., 2004).”
- Targeting oncogenic Myc as a strategy for cancer treatment (2018, background): “Upon phosphorylation at Thr58, Myc is polyubiquitinated by the E3 ligase FBW7 and degraded by the proteasome.(43) The human FBW7 locus encodes three protein isoforms, FBW7α, FBW7β, and FBW7ɣ, that differ in their N-terminal sequences and in their subcellular localization.”
- Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis (2017, background): “FBXW7a could target c-Myc, a key regulator of tumorigenesis, for ubiquitination-induced degradation (33).”
- Neuroblastoma and MYCN (2013, unknown): “4) (Sears et al. 2000; Welcker et al. 2004; Yada et al. 2004).”
- c-Myc and Cancer Metabolism (2012, unknown): “This includes phosphorylation-dependent degradationof cMyc (18).”