Identification and proteomic profiling of exosomes in human urine.

By T. Pisitkun, Rong‐Fong Shen, M. Knepper. Proceedings of the National Academy of Sciences of the United States of America, 2004

2,095 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Nephrology

View Paper: https://www.semanticscholar.org/paper/77e23619bc0869484ef11c418a50a9d229c2786f

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Citations in the corpus

Exosomes: extracellular organelles important in intercellular communication. (2010, methodology): “Exosomes have also been isolated from physiological fluids such as normal urine [24,25,84,85], malignant and pleural effusions [83,86], bronchial lavage fluid [87], ocular fluids [88], human semen [89,90], amniotic fluid [91], human saliva [39,92], breast milk [37], pregnancy-associated sera [93] an”
Exosomes are released by cultured cortical neurones. (2006, background): “Membrane trafficking (P48037) Annexin 6 2 (Pisitkun et al., 2004)”
Engineering exosomes for targeted drug delivery (2021, background): “Exosomes are now widely found in all bodily fluids and tissues, including blood [6], urine [7], breast milk [8], amniotic/synovial/ascites fluid [9], saliva [10], and adipose tissue [11].”
ExoCarta 2012: database of exosomal proteins, RNA and lipids (2011, background): “Recent studies have shown that exosomes can be isolated in vivo in bodily fluids such as blood (8), urine (9), breast milk (10), amniotic fluid (11), malignant ascites (12), bronchoalveolar lavage fluid (13) and synovial fluid (14).”
Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications (2020, neutral): “69 Due to the complicated operation of TEM and higher requirements on sample preparation than SEM, it is not suitable for rapid measurement of a large number of samples.”
Exosomes: a common pathway for a specialized function. (2006, background): “In addition there is increasing evidence for the presence of exosomes in physiological fluids such as plasma (14), malignant and pleural effusions (15, 16) and urine (17).”
Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis (2019, background): “While the exact mechanism is still not fully understood, it appears the formation of MVBs can be stimulated by growth factors and the cell adjusts its exosome production according to its needs [29,46].”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “However, it was as recent as 2004 that urinary EVs were first depicted as such (18) and it has now been estimated that only about 3% of the total urinary protein content is derived from EVs.”