Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.

By C. Tsou, W. Peters, Y. Si, S. Slaymaker, A. Aslanian, S. Weisberg, M. Mack, I. Charo. Journal of Clinical Investigation, 2007

1,153 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/77caa3d7752cd629a53ea71899881b82b4a5bf19

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. F. Geissmann
2. P. Italiani
3. D. Boraschi
4. Eric G. Pamer
5. C. Auffray
6. C. Shi
7. M. Sieweke
8. L. Chávez-Galán

In Oncology

1. F. Geissmann
2. Eric G. Pamer
3. L. Chávez-Galán
4. I. Garcia
5. D. Vesin
6. Maria L. Olleros
7. N. Serbina

Citations in the corpus

• Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, background): “In contrast, although they are poor antigen-presenting cells, human monocytes express MHC class II antigens (106) and the integrin CD11c.”
• Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System (2020, background): “[166] [167] [168] [169] [170] [171] In addition to an increase in myeloidosis, diabetics with complications have reduced bone marrow-derived vascular reparative cells and circulating angiogenic cells (CD34 + cells).”
• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “Fibroblasts, epithelial, and endothelial cells produce CCL2 in response to inflammatory cytokines or microbial molecules, and generate a high level of this chemokine in the inflamed tissue (to allow egress of monocytes from the blood and entry in the tissues) and/or in blood (to allow entry of bone ”
• Monocyte-mediated defense against microbial pathogens. (2008, background): “In contrast, MCP-2/5−/− mice have normal circulating monocyte numbers, indicating that MCP-1 and MCP-3 are the predominant CCR2 ligands maintaining homeostatic numbers of circulating inflammatory monocytes (30).”
• Monocyte recruitment during infection and inflammation (2011, background): “CC-chemokine ligand 2 (CCL2; also known as MCP1) and CCL7 (also known as MCP3) are CC-chemokines that bind to CCR2 and mediate LY6C hi monocyte recruitmen”
• Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal (2013, background): “Ly6C+ monocytes exit the bonemarrow and extravasate into peripheral inflamed tissues, partly in response to chemokines that signal via C-C chemokine receptor type 2 (CCR2) (Serbina and Pamer, 2006; Tsou et al., 2007).”
• Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, background): “It has been established that CCR2 and the chemokine chemoattractant protein 3 (MCP-3) are critical for BM monocyte mobilization and homeostasis maintenance (9).”