Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

By Ralph R. Alcendor, Shumin Gao, P. Zhai, Daniela K. Zablocki, E. Holle, Xianzhong Yu, Bin Tian, T. Wagner, S. Vatner, J. Sadoshima. Circulation Research, 2007

1,117 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/7752eb5e2fa6cfb667b72e910d975c0dd51f0661

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. D. Sinclair
2. L. Guarente
3. Hung-Chun Chang
4. T. Horvath
5. M. Haigis
6. C. Kenyon
7. Johan Auwerx
8. F. Picard

In Geriatrics and Gerontology

1. D. Sinclair
2. L. Guarente
3. Hung-Chun Chang
4. Alexander S. Banks
5. M. Haigis
6. Johan Auwerx
7. E. Verdin
8. C. Cantó

In Physiology

1. D. Sinclair
2. Hung-Chun Chang
3. L. Guarente
4. Alexander S. Banks
5. T. Horvath
6. M. Haigis
7. Johan Auwerx
8. E. Verdin

Citations in the corpus

• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “NAD-dependent SIRT1 is significantly upregulated in response to oxidative stress, protecting heart from oxidative damage, contributing to retard of aging.(362)”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “SIRT1-mediated cardiac benefits occurred when SIRT1 expression levels were low to moderate; in contrast, high doses of SIRT1 exacerbated oxidative stress and induced cardiomyopathy (8).”
• SIRT1 and other sirtuins in Metabolism (2013, background): “However, high levels of cardiac-specific expression of SIRT1 can be detrimental [88].”
• Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “In the heart, SIRT1 regulates aging and resistance to oxidative stress.(70) PGC-1a activity is also potentiated by arginine methylation, which is catalysed by protein arginine methyltransferase-1 (PRMT1), another nuclear receptor co-activator.”
• Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (2011, background): “The protective function of Sirt1 has been reported in other organs such as the heart, neurons, lung, liver [67,68,69,70].”
• Redox regulation of FoxO transcription factors (2015, background): “The physiological relevance of this regulation was later demonstrated in mouse models of oxidative stress-induced heart failure [124,125].”