Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

By N. Gale, Gavin Thurston, S. Hackett, R. Renard, Quan Wang, J. McClain, Clifford P. Martin, C. Witte, M. Witte, D. Jackson and 4 more. Developmental Cell, 2002

1,052 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/771350882fda8f1d2cbb063b8ad40b24000e6a54

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. K. Alitalo
2. Peter Carmeliet
3. Rakesh K. Jain

In Molecular Biology

1. K. Alitalo
2. T. Tammela
3. Gavin Thurston
4. H. Augustin
5. Ulrike Fiedler
6. G. Koh
7. Rakesh K. Jain
8. N. Ferrara

In Oncology

1. K. Alitalo
2. T. Tammela
3. Rakesh K. Jain
4. N. Ferrara
5. M. Shibuya
6. M. Swartz
7. H. Wiig

Citations in the corpus

• Molecular cues to implantation. (2004, neutral): “development of lymphatic vasculature (343).”
• The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. (2004, methodology): “The mechanistic understanding of Ang-2 function is furthermore complicated by the fact that Ang-2 is almost exclusively produced by endothelial cells.(12,15-20) As such, it acts as an autocrine regulator of endothelial cell functions.”
• TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. (2008, neutral): “, 2003), and are in line with the role of the angiopoietin and angiopoietin-like factors in vascular remodeling (Camenisch et al., 2002; Gale et al., 2002; Parikh et al., 2006).”
• Lymphangiogenesis: Molecular mechanisms and future promise. (2010, background): “…impaired smooth muscle cell recruitment to the collecting vessels and hypoplastic lymphatic capillaries, suggesting that Ang2 is needed for lymphatic vessel stabilization (Gale et al., 2002 sufficient to rescue the lymphatic phenotype but not the blood vascular phenotype (Gale et al., 2002).”
• Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2–Tie2 complex (2006, background): “These studies have shown that the differential angiopoietin activities are controlled at the level of the target cell, differing, for example, in blood-vessel endothelial cells and lymphatic endothelial cell”
• Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system (2009, background): “Developmental angiogenesis in ANG2-deficient mice is not perturbed and newborn pups are born apparently norma”
• Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation (2006, background): “In turn, the antagonistic ligand Ang-2 acts by an autocrine mechanis”
• Lymphangiogenesis in development and human disease (2005, background): “Angpt2 -gene-targeted mice display lymphatic hypoplasia, but replacement of Angpt2 with Angpt1 was sufficient to rescue the lymphatic vascular phenotyp”