Lymphangiogenesis: Molecular mechanisms and future promise.
By T. Tammela, K. Alitalo. Cell, 2010
1,409 citations recorded by the source corpus.
The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases.
Subfields: Molecular Biology, Oncology, Surgery
View Paper: https://www.semanticscholar.org/paper/c2145d4aec4c6f7ac0272cef320fffee65ff78b7
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Citations in the corpus
- Tumors as organs: complex tissues that interface with the entire organism (2010, neutral): “The lymphatic vessels also transport antigen-presenting cells to lymph nodes (reviewed in Tammela and Alitalo, 2010).”
- Hallmarks of cancer: the next generation. (2011, neutral): “Closely related to the endothelial cells of the general circulation are those forming lymphatic vessels (Tammela and Alitalo, 2010).”
- The lymphatic vasculature in disease (2011, background): “However, the new findings in mouse and pig models described above suggest that the transfer of chains of lymph nodes from another location in the patient could be combined with VEGF-C treatment to form lymphatic microvascular anastomose”
- Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “In tumors, lymphangiogenesis has obvious importance as a route for cancer cells to disseminate to lymph nodes, and lymphatic vessels are known to secrete a wide range of chemokines that attract tumor cells, including CCL5 and CCL21 (210, 426, 459).”
- Molecular mechanisms and clinical applications of angiogenesis (2011, background): “VEGFR-3 is necessary for the formation of the blood vasculature during early embryogenesis, but later becomes a key regulator of lymphangiogenesis — the formation of new lymphatic vessels from pre-existing one”