The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies.

By Ulrike Fiedler, Marion Scharpfenecker, Stefanie Koidl, Anja Hegen, V. Grunow, Jarno M. Schmidt, W. Kriz, Gavin Thurston, H. Augustin. Blood, 2004

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Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system (2009, background): “Endothelial storage of ANG2 Not only do ECs produce ANG2 by transcriptional activation, but they also store it in specialized endothelial storage granules, the so-called Weibel–Palade bodies , in which it colocalizes with the haemostasis-regulating glycoprotein von Willebrand Factor ( vWF”
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. (2011, result): “In agreement with previous findings (Fiedler et al., 2004), our gene expression data indicate that ANG2 is highly expressed in tumor ECs (Figure S4).”
Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation (2006, background): “and is stored in endothelial Weibel-Palade bodies from where it can be rapidly released upon stimulatio”
Hypoxia signalling in cancer and approaches to enforce tumour regression (2006, neutral): “Therefore Ang-2 secretion from Weibel–Palade bodie”