Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance

By C. Weyer, J. Foley, C. Bogardus, P. Tataranni, R. Pratley. Diabetologia, 2000

803 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/7702640158cc73f615236e15d4c7daac13792dc9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. André Tchernof
2. M. Blüher
3. Ralph DeFronzo
4. J. Despres

In Endocrinology, Diabetes and Metabolism

1. André Tchernof
2. J. Despres
3. Ralph DeFronzo
4. M. Blüher
5. S. Grundy
6. I. Tabas
7. K. Bornfeldt

In Epidemiology

1. André Tchernof
2. Ralph DeFronzo
3. J. Despres
4. Alexander Sakers
5. Mirian Krystel De Siqueira
6. P. Seale
7. K. Frayn
8. M. Blüher

Citations in the corpus

• Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology (2009, background): “There is, however, a large inter-individual variation in adipocyte size among lean and obese individuals (10; 18; 19).”
• Adipose tissue plasticity in health and disease (2022, background): “Hypertrophic adipose tissue is dysfunctional Hypertrophic expansion of adipose tissue is a risk factor, independent of body-mass index, for the development of the metabolic syndrome (Weyer et al., 2000).”
• Insulin-sensitive obesity. (2010, background): “The primary signal causing adipose tissue dysfunction and insulin-resistant obesity could be adipocyte hypertrophy, since enlarged adipocytes are more insulin resistant and produce a proinflammatory adipokine pattern (34, 47).”
• Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, neutral): “precedes the development of type 2 diabetes((63)), a growing”
• Relationship between adipocyte size and adipokine expression and secretion. (2007, background): “Recently, adipocyte size in the sc abdominal depot was identified to be a significant predictor for the future development of diabetes mellitus type 2 (5).”
• Pathophysiology of human visceral obesity: an update. (2013, background): “Subcutaneous adipocyte size is related to measures of insulin resistance in both women and men (13, 221, 305, 336, 615).”
• Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “The overflow hypothesis also explains the well documented observation that enlarged fat cells correlate better with insulin resistance than any other measure of adiposity (249– 252) and that enlarged fat cells are a strong, independent predictor of the development of type 2 diabetes (253).”
• Adipose tissue as a buffer for daily lipid flux (2002, background): “Furthermore, the occurrence of larger adipocytes in the subcutaneous abdominal depot is a marker of risk of developing Type II diabetes [73, 74].”