Relationship between adipocyte size and adipokine expression and secretion.

By T. Skurk, C. Alberti-Huber, C. Herder, H. Hauner. Journal of Clinical Endocrinology and Metabolism, 2007

1,323 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/93109e48c2c8e6d15f39c65d041c61a8983c500b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Sushil Kumar Jain
2. M. Blüher

In Epidemiology

1. André Tchernof
2. J. Despres
3. Myung‐Sook Choi
4. M. Trujillo
5. Sushil Kumar Jain
6. Prasenjit Manna
7. M. Blüher
8. U. Jung

In Physiology

1. J. Despres
2. Myung‐Sook Choi
3. M. Trujillo
4. Sushil Kumar Jain
5. André Tchernof
6. M. Blüher
7. U. Jung
8. R. Eckel

Citations in the corpus

• Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. (2008, background): “Plasma adipocytokine levels rise with an increase in adipose tissue and adipocyte volume, except for plasma adiponectin which is lower in obesity.(11,12) The essential roles of adipose tissue are exemplified by the fact that total absence of adipose tissue results in non-viability as occurs in homoz”
• Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “Considering adipocytes are rather large cells, with diameters of up to 200 m (42), the hypoxic phenomenon is prone to be relevant based on the sheer size of the adipocyte.”
• Insulin-sensitive obesity. (2010, background): “The primary signal causing adipose tissue dysfunction and insulin-resistant obesity could be adipocyte hypertrophy, since enlarged adipocytes are more insulin resistant and produce a proinflammatory adipokine pattern (34, 47).”
• Pathophysiology of human visceral obesity: an update. (2013, background): “Again, adipocyte size and adipose tissue distribution are key determinants of inflammatory cytokine secretion (129, 189, 215, 226, 517).”
• Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth (2009, background): “, insulin resistance [9] and adipokine secretion [10], depend on the precise cell-size distribution rather than the mean cell size.”
• Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. (2014, background): “was shown that enlarged adipocytes themselves produce pro-inflammatory cytokines and chemokines [32], adipose tissue macrophages seem to be crucial for the production of adipose”
• Metabolism Disrupting Chemicals and Metabolic Disorders (2016, neutral): “Furthermore, it is well documented that while it is possible to lose weight and keep it off for an extended time, the vast majority of people will gain the weight back, perhaps indicating they are fighting against a set point or sensitivity to develop these metabolic problems that favors calorie sto”
• Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology (2009, background): “Detailed classification requires the separation of isolated adipocytes according to size (15,17), which is not feasible using small amounts of adipose tissue.”
• The metabolic syndrome. (2008, background): “Since the earliest report of the presence of monocyte-derived macrophages in human adipose tissue by Ferrante and colleagues (141), it is now clear that larger fat cells also produce more cytokines (142).”