Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

By O. Vakhrusheva, Christian Smolka, P. Gajawada, S. Kostin, T. Boettger, T. Kubin, Thomas Braun, E. Bober. Circulation Research, 2008

627 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Oncology

View Paper: https://www.semanticscholar.org/paper/1019ad664ddf595797c2090e165701fd16d45b4a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. E. Seto
2. Xiang-Jiao Yang
3. Johan Auwerx
4. L. Guarente

In Geriatrics and Gerontology

1. Johan Auwerx
2. C. Cantó
3. R. Houtkooper
4. Keir J. Menzies
5. E. Seto
6. Xiang-Jiao Yang
7. Hung-Chun Chang
8. R. Wanders

In Oncology

1. Johan Auwerx
2. C. Cantó
3. E. Seto
4. R. Houtkooper
5. L. Guarente
6. Xiang-Jiao Yang
7. S. Imai

Citations in the corpus

• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “Four deacetylases (HDAC1, HDAC3, SIRT1, and SIRT7) have been shown to deacetylate p53 (Brooks and Gu, 2003; Zeng et al., 2006; Vakhrusheva et al., 2008).”
• SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation (2012, neutral): “2e, f and Supplementary Figs 6 and 7), whereas depletion of HDAC1 (which can also deacetylate H3K18Ac 9 ) did not (Supplementary Fig.”
• SIRT1 and other sirtuins in Metabolism (2013, background): “Both SIRT6 and SIRT7 deficient mice displayed cardiac hypertrophy phenotype due to upregulated IGF signaling and p53 activity, respectively [90,91].”
• Sirtuins as regulators of metabolism and healthspan (2012, background): “SIRT7 may also deacetylate p53: Sirt7 −/− mice display cardiac hypertroph”
• The Role of Sirtuins in Antioxidant and Redox Signaling (2017, background): “Interestingly, SIRT7 knockout mice have been characterized by lethal heart hypertrophy and a progeroid phenotype, manifesting as premature physiological aging, making affected individuals appear to be older than they are (163).”
• The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “Considering SIRT7 as a positive regulator of rDNA, it is striking that presumably SIRT7 may also have an antiproliferative role, as evidenced in loss- and gain-offunction cell-based models (127).”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “…susceptibility to metabolic and age-related disease or reduced maximal lifespan (Boutant and Canto, 2014; Hirschey et al., 2011; Ryu et al., 2014; Vakhrusheva et al., 2008), while the absence of SIRT6 causes severe hypoglycemia, leading to mortality within the first month of life (Mostoslavsky…”