Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

By K. Haglund, S. Sigismund, Simona Polo, I. Szymkiewicz, Pier Paolo Di Fiore, Ivan Dikic. Nature Cell Biology, 2003

870 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/75eef3ab1a2a6e3f342658b129087a2e37041c1f

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Citations in the corpus

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins (2009, background): “In support of this idea, the ESCRT cargo that has been most extensively studied in mammalian cells, EGFR, is known to become conjugated to several ubiquitin molecules in response to high EGF concentratio”
Biogenesis and function of multivesicular bodies. (2007, background): “…proteins are modified by several Ubs, yet these either are linked directly to substrate proteins via several lysine residues (multiple monoubiqitination) (Haglund et al. 2003) or may be present in short oligo-Ub chains consisting of lysine 63 (K63)-linked Ubs (Hicke & Dunn 2003, Dupre et al. 2001).”
Clathrin-mediated endocytosis in AP-2–depleted cells (2003, background): “These observations indicate that the receptor must have another signal (or signals) for endocytosis, and there is increasing evidence that ubiquitin may be that signal (Haglund et al., 2003).”
Ubiquitylation and cell signaling (2005, background): “In cells, the affinity and specificity of the interaction to mono-Ub might be increased by additional interactions with the modified protein or formation of multimeric complexes of Ub-binding proteins (Di Fiore et al, 2003; Haglund et al, 2003a).”
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling (2005, background): “, has emerged as an important signal in mammalian endocytic pathway”
Atypical ubiquitin chains: new molecular signals (2008, background): “…ligase cBL mediates multiple monoubiquitination and Lys 11-, Lys 48- and Lys 63-oligoubiquitination of activated epidermal growth factor receptor (EgFr; Haglund et al, 2003; Mosesson et al, 2003; Huang et al, 2006), as well as Lys 48-linked polyubiquitination of Src kinases (thien & Langdon, 2005).”
Lysosomes: fusion and function (2007, background): “Other ligands, such as epidermal growth factor (EGF), remain bound to their receptors (which are ubiquitylate”
Insights in Post-Translational Modifications: Ubiquitin and SUMO (2022, background): “While the role of monoubiquitination in the DNA damage response has been predominantly studied in histones and associated to malignancies and neurodevelopmental disorders [56–58], multi-monoubiquitination has been mainly reported in endocytosis [59].”
Post-translational modifications in signal integration (2010, background): “The EGFR is multiply monoubiquitinated or polyubiquitinated through Lys63 chains that mark it for lysosomal degradatio”
RING domain E3 ubiquitin ligases. (2009, background): “King, personal communication) but most often probably does not function as a proteasome-targeting signal in vivo, as exemplified by modification and lysosomal targeting of the EGF receptor by c-Cbl (88).”