Atypical ubiquitin chains: new molecular signals

By Fumiyo Ikeda, Ivan Dikic. EMBO Reports, 2008

981 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/05fb2f5d169cd576b991ca89bea4a43b96d568f2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Komander
2. Ivan Dikic
3. Jian Lei
4. Daniela Hoeller
5. Rolf Hilgenfeld
6. Y. Kusov

In Molecular Biology

1. R. Youle
2. D. Komander
3. Ivan Dikic
4. L. A. Kane
5. Derek P. Narendra
6. S. Urbé
7. M. J. Clague
8. Tony Pawson

In Oncology

1. D. Komander
2. Ivan Dikic
3. Daniela Hoeller
4. Tony Pawson
5. Jian Lei
6. K. Wilkinson
7. Rolf Hilgenfeld
8. R. Youle

Citations in the corpus

• A role for ubiquitin in selective autophagy. (2009, background): “Due to the presence of internal Lys residues, Ub can repeatedly be attached to itself, forming chains with various topologies and functions (Ikeda and Dikic, 2008).”
• Ubiquitination and selective autophagy (2012, background): “Dependent on which of its seven lysine (K) residues is linked to the ubiquitin monomer, the chains are called K6, K11, K27, K29, K33, K48 or K63 ubiquitin chains.(12) Conjugation on its amino terminal methionine (M1) moieties leads to the formation of linear chains.”
• Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein (2017, background): “…Ub chains mainly cause target protein degradation via the 26S proteasome, while Lys63-linked polyUb is mainly related to DNA repair and signal transduction (Ikeda and Dikic, 2008), in particular, in the signal transduction cascades of the host innate immune system (Dikic and Dötsch, 2009).”
• Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. (2011, neutral): “In addition, mono- and polyubiquitination of protein targets using different Ub lysine residue linkages facilitate regulation of subcellular localization, chromatin structure, signal transduction, ribosomal protein synthesis and DNA damage repair (Ikeda and Dikic, 2008).”
• The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “Moreover, the function of Ub ligases can also be reversed by deubiquitinases (DUBs), which are also critical for almost all cellular signaling pathways, such as the cell cycle, apoptosis, receptor downregulation and gene transcription, by removing Ub from substrate proteins.(4,5) Proteins are the fu”
• Targeting the ubiquitin system in cancer therapy (2009, background): “Ubiquitin contains seven acceptor lysines that can participate in ubiquitin conjugation, giving rise to ubiquitin chains of different topologies, lengths and functional outcome”
• Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains (2009, background): “Importantly, ubiquitin itself has seven lysine residues, all of which can act as acceptors for further ubiquitination, generating polyubiquitin chains”