The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

By Y. Ye, Hemmo Meyer, Tom A. Rapoport. Nature, 2001

1,167 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/757e6d8ed3978d70e401935e0c6ef442557cdfaa

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Citations in the corpus

PINK1- and Parkin-mediated mitophagy at a glance (2012, background): “…for endoplasmic-reticulum-associated protein degradation (ERAD) to dislocate the ubiquitylated proteins from the ER to the cytosol to make them accessible for proteasomal degradation (Rabinovich et al., 2002; Ye et al., 2001), was found to translocate to depolarized mitochondria along with Parkin.”
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin (2010, background): “We therefore examined if Mfn degradation requires the activity of p97, a AAA+ ATPase involved in the retrotranslocation of ER membrane-spanning proteins after ubiquitination and en route to proteasomal degradation (Ye et al., 2001; Rabinovich et al., 2002).”
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. (2012, positive): “Identification of individual bands by mass spectrometry revealed Rqc1, Ltn1, and the conserved and poorly ), and its cofactors Ufd1 and Npl4 (Ye et al., 2001) were present at lower amounts in the sample, which is consistent with the expected 1:6 stoichiometry.”
Retro-translocation of proteins from the endoplasmic reticulum into the cytosol (2002, background): “Substrates at the ER membrane seem to carry somewhat shorter polyubiquitin chains than those in the cytoso”
Protein quality control in the early secretory pathway (2008, background): “It remains to be seen whether derlins directly mediate dislocation, or act by recruiting additional essential components such as the AAA-ATPase p97, which provides part of the energy neces- sary for this step (Ye et al, 2001, 2004; Rabinovich et al, 2002; Oda et al, 2006).”
Peroxisomal-protein import: is it really that complex? (2002, positive): “In addition, it has recently been shown that Cdc48/VCP — the AAA ATPase that is most closely related to PEX1 and PEX6 — is required for the retro-translocation of proteins from the ER lumen to the cytoplas”
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. (2002, background): “However, recent findings that a complex of Cdc48/p97/VCP (an AAA ATPase family member), Udf1 (a protein involved in the degradation of ubiquitin fusion proteins at post-ubiquitination steps), and Npl4 is required for the extraction of proteins from the ER to cytosol (Ye et al. 2001), and that Cdc48/”
Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control (2012, background): “the retrotranslocation of ER membrane-spanning proteins after their ubiquitination.(151) Thus, these data suggest that degradation”