Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

By Billy Tsai, Y. Ye, Tom A. Rapoport. Nature reviews. Molecular cell biology, 2002

698 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Plant Science

View Paper: https://www.semanticscholar.org/paper/ae044a61778ac844e71bcc0fc07ca5148f796cac

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Citations in the corpus

Phagosomes are competent organelles for antigen cross-presentation (2003, methodology): “Some of these peptides are then retrotranslocated to the cytoplasmic side of phagosomes by the Sec61/chaperones retrotranslocation machinery normally used for quality contro”
Cellular response to endoplasmic reticulum stress: a matter of life or death (2006, background): “Mammalian ERAD pathways are less well understood than those of yeast, but several parallels are clear.(8,9) As in yeast,”
Virus Entry: Open Sesame (2006, positive): “Interestingly, a similar mechanism may explain how the cholera toxin A chains penetrate into the cytosol (Tsai et al., 2002).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, neutral): “However, depending on the source and type of the cell used, this translocation process can be explained by either power stroke or Brownian ratchet [1290, 1291, 1292, 1293, 1294].”
Quality control in the endoplasmic reticulum (2003, background): “As ERAD has recently been reviewed in detail in this journa”
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. (2006, background): “However, the experiments implicating Sec61p in ERAD are not entirely convincing (for a discussion, see Tsai et al., 2002), and other candidates have been proposed, including the ubiquitin ligase Hrd1p (Gauss et al., 2006) and Der1p (Lilley and Ploegh, 2004; Ye et al., 2004), a membrane protein that…”
Elements of the ERAD ubiquitin ligase Doa10 regulating sequential poly-ubiquitylation of its targets (2022, positive): “6 iScience 25, 105351, November 18, 2022 Ubc7 to the ER membrane, stabilizes Ubc7 levels, and stimulates Ubc7 E2 activity (Bazirgan and Hampton, 2008; Biederer et al., 1997; Chen et al., 1993; Ravid and Hochstrasser, 2007; von Delbruck et al., 2016).”
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol (2004, background): “These proteins are eventually degraded by the proteasome and must therefore be transported back into the cytosol by a multi-step process called retro-translocation, dislocation, or ERAD (for ER-associated protein degradation) (for review, see ref”
Quality control in the endoplasmic reticulum protein factory (2003, background): “To maintain homeostasis, terminally misfolded molecules are 'retrotranslocated' or 'dislocated' across the ER membrane to be degraded by cytosolic proteasome”
Protein quality control in the early secretory pathway (2008, background): “…function of PDI (Wilkinson and Gilbert, 2004; Forster et al, 2006a), particularly with terminally mis- folded proteins, which must be reduced before dislocation to the cytosol for proteasomal degradation (Gillece et al, 1999; Fagioli et al, 2001; Tsai et al, 2001, 2002; Molinari et al, 2002).”