Non-coding RNAs as regulators of embryogenesis

By A. Pauli, Johannes Rinn, A. Schier. Nature reviews genetics, 2011

630 citations recorded by the source corpus.

Non-coding RNAs (ncRNAs) are emerging as key regulators of embryogenesis. They control embryonic gene expression by several means, ranging from microRNA-induced degradation of mRNAs to long ncRNA-mediated modification of chromatin. Many aspects of embryogenesis seem to be controlled by ncRNAs, including the maternal–zygotic transition, the maintenance of pluripotency, the patterning of the body axes, the specification and differentiation of cell types and the morphogenesis of organs. Drawing from several animal model systems, we describe two emerging themes for ncRNA function: promoting developmental transitions and maintaining developmental states. These examples also highlight the roles of ncRNAs in ensuring a robust commitment to one of two possible cell fates.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/46567205d584a0d9d39b1c730e1dd1d5eb22ae47

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Igor Ulitsky
2. David P. Bartel
3. Johannes Rinn
4. D. Reinberg
5. Wee-Wei Tee
6. P. Voigt
7. Aviv Regev
8. Guodong Yang

In Molecular Biology

1. Igor Ulitsky
2. David P. Bartel
3. Johannes Rinn
4. Aviv Regev
5. P. Voigt
6. Wee-Wei Tee
7. D. Reinberg
8. A. Schier

Citations in the corpus

• Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis. (2012, background): “While miRNAs (microRNAs), the best-studied class of sRNAs, regulate their mRNA targets post- transcriptionally (Bartel 2009), mRNA-like lncRNAs act by a range of mechanisms (for reviews, see Koziol and Rinn 2010; Pauli et al. 2011; Wang and Chang 2011).”
• Gene regulation by the act of long non-coding RNA transcription (2013, background): “LncRNAs - a new layer of genome regulatory information It is now well appreciated that less than two percent of the human genome codes for proteins and the majority of the genome gives rise to non-protein-coding RNAs (ncRNAs) [1], which are predicted to play essential roles in a variety of biologica”
• LncRNA: a link between RNA and cancer. (2014, background): “mechanisms how lncRNA regulates the chromatin structure and transcriptional control [5, 22, 23].”
• Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage (2012, neutral): “Long ncRNAs (lncRNAs) are noncoding polyadenylated transcripts with emerging roles in gene regulation (Pauli et al., 2011).”
• A double take on bivalent promoters. (2013, background): “Expression profiles of several types of ncRNAs suggest that they are involved in cell fate decisions (Jacquier 2009; Guttman et al. 2011; Pauli et al. 2011).”
• Control of somatic tissue differentiation by the long non-coding RNA TINCR (2012, neutral): “For secondary structure analysis, the following TINCR radiolabelled RT primers were used: (1) 59-CCTTGATGTGGTAGCGCTTCCAGCGC-39; (2) 59-AGACA GGGCACCCAGGGCCCCAAGAGG-39; (3) 59-TGTCCTGGGCAAGAGCGGA AGTGCCTC-39; (4) 59-AAAGCAGCTCCAGCAGGTCTGCCTGCCG-39; (5) 59-GGGCACACAGTGGGTCTCTGGGGACAAAG-39; (6) 59-TACT”
• lincRNAs: Genomics, Evolution, and Mechanisms (2013, positive): “, 1996), clearly are functional, and the roster of biological processes in which long noncoding RNAs are reported to play key roles is rapidly growing and now includes cell-cycle regulation, apoptosis, and establishment of cell identity (reviewed in Ponting et al., 2009; Pauli et al., 2011; Rinn and”
• Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress (2015, background): “During normal embryogenesis, stores of maternal mRNA initially present in the zygote are selectively degraded postfertilization, and miR function within the zygote RISC complex is essential to this developmental process (39, 40).”