Endoplasmic reticulum–mitochondria contacts: function of the junction
By Ashley A. Rowland, G. Voeltz. Nature reviews. Molecular cell biology, 2012
1,005 citations recorded by the source corpus.
The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER–mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER–mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca2+ signalling and the control of mitochondrial biogenesis and intracellular trafficking.
Subfields: Clinical Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/749541d4a7b5442942f27c17913264bf89fcaf47
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Citations in the corpus
- 13 reasons why the brain is susceptible to oxidative stress (2018, background): “dria contacts, termed ER associated mitochondria membranes (MAM [48,49]), leading to mitochondrial Ca uptake.”
- A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles (2014, background): “It is now clear that there is extensive biochemical cross talk between organelles, but the mechanisms are only beginning to emerge (Sheftel et al, 2007; Zehmer et al, 2009; Rowland & Voeltz, 2012; Mesmin et al, 2013).”
- Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “An interesting feature of mitochondrial and peroxisomal biology is that these organelles interact at the MAM, a specialized subdomain of the endoplasmic reticulum (26, 208).”