Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

By B. Czéh, T. Michaelis, Takashi Watanabe, Jens Frahm, G. de Biurrun, M. van Kampen, A. Bartolomucci, E. Fuchs. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,124 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/73353439e4548a56ca37e85d84c90e61c530299d

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Citations in the corpus

The role of the hippocampus in the pathophysiology of major depression. (2004, neutral): “The behavioural and mood abnormalities associated with mood disorders appear to arise as the result of disturbances in a temporolimbic–frontal–caudate network.(1,2) Normal regulation of mood may depend on the integrity of pathways linking the paralimbic frontal cortex and the basal ganglia.”
Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. (2008, background): “There are many hormonal, neurochemical and behavioral modulators of neurogenesis and cell survival in the dentate gyrus including estradiol, insulin-like growth factor-1, antidepressants, voluntary exercise and hippocampal-dependent learning (Aberg et al., 2000; Trejo et al., 2001; Czeh et al., 2001”
Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment (2003, background): “Previous studies have demonstrated that physiologically relevant stressors, including psychosocial stress, intruder stress, and predator odor (Gould et al, 1997, 1998; Tanapat et al, 1998; Czeh et al, 2001) decrease hippocampal proliferation.”
Untreated depression and hippocampal volume loss. (2003, background): “Animal studies have shown antidepressants to protect against stress-induced decrease in neurogenesis with preservation of hippocampal volume during a social stress paradigm (13).”
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus (2005, background): “In stress and depression, where the total number of granule cells may be reduced (McEwen, 1999; Czeh et al., 2001), antidepressants may lead to an initial increase in the total number of cells, but over time this increasing effect may be balanced by increased apoptosis to maintain normal amounts of…”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Chronic administration of the atypical antidepressant tianeptine (Czeh et al., 2001) or the TCA clorimipramine (Van der Hart et al.”
The enduring effects of abuse and related adverse experiences in childhood (2006, background): “Early environmental deprivation inhibits hippocampal neurogenesis; conversely, neurogenesis is enhanced by enriched environment (Kempermann 1997), learning (Gould 1999a) and at times, some antidepressant treatments (Malberg 2000; Czeh 2001).”
The stress system in the human brain in depression and neurodegeneration. (2005, background): “Also, a study in psychologically stressed tree shrews, considered to be a good model for HPA alterations in depression, showed reduced hippocampal volume, associated with reduced numbers of BrdU-positive newborn cells, which, interestingly, normalized following antidepressant treatment (Czéh et al.,”
Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus (2003, background): “Studies of repeated psychosocial stress in tree shrews have also documented dendritic remodelling in CA3 and reduced DG neurogenesis, accompanied by either impairment on hippocampaldependent memory processes (Magarinos et al., 1996; Gould et al., 1997; Ohl & Fuchs, 1999; Czeh et al., 2001).”