Untreated depression and hippocampal volume loss.

By Yvette I. Sheline, M. Gado, H. Kraemer. American Journal of Psychiatry, 2003

1,222 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/f01dae63ba869388576c3356fbf94917d6211320

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Citations in the corpus

TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, background): “TrkB Is Required for Induced Proliferation and Neurogenesis by ADs and Voluntary Exercise Reduction in hippocampal volume has been observed in animal models of stress (Coe et al., 2003; Czeh et al., 2001), which may be reversed or prevented by chronic AD treatment (Sheline et al., 2003).”
Neurocircuitry of Mood Disorders (2010, background): “…reflect clinical heterogeneity, as one study reported that reduced hippocampal volume was limited to depressed women who suffered early-life trauma (Vythilingam et al, 2002), whereas others reported that hippocampal volume correlated inversely with time spent depressed (eg, Sheline et al, 2003).”
Clinical Staging of Psychiatric Disorders: A Heuristic Framework for Choosing Earlier, Safer and more Effective Interventions (2006, background): “early vs late-onset) or is simply a correlate of duration of untreated illness [13].”
Prospective reports of chronic life stress predict decreased grey matter volume in the hippocampus (2007, background): “First, among individuals with major depression, a longer lifetime experience of untreated and recurrent depressive episodes predicts a decreased volume of the hippocampus (MacQueen et al., 2003; Sheline et al., 2003; Sheline et al., 1999; Sheline et al., 1996).”
A Review of Adversity, The Amygdala and the Hippocampus: A Consideration of Developmental Timing (2009, neutral): “In human adults, stress-related pathologies, such as major depressive disorder and post-traumatic stress disorder (PTSD), correlate with decreased hippocampal volume (Sheline et al., 2003; Campbell et al., 2004; Geuze et al., 2005; Kitayama et al., 2005; Smith, 2005) and altered activity (Bremner, 2”
Gray matter abnormalities in Major Depressive Disorder: a meta-analysis of voxel based morphometry studies. (2012, background): “Trauma, stress, psychological and social factors undoubtedly play a role in the etiology of MDD, but neuroimaging, neuropathological and familial studies also point to a role for biological factors (Hasler, 2010; Lorenzetti et al., 2009; Rajkowska et al., 1999; Sheline et al., 2003; Sullivan et al.,”
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, background): “that antidepressant treatment can reverse or block hippocampal atrophy (Sheline et al., 2003; Vermetten et al., 2003).”
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action (2006, background): “The hippocampus is one brain region that has been implicated in the pathophysiology of depression: human patients suffering from depression have reduced hippocampal volume”
Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments (2019, background): “There is also evidence of increases of hippocampal volume with successful treatment indicating reversibility (MacQueen et al., 2008; Sheline, 2003).”