Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.

By S. Ikemoto. Brain Research Reviews, 2007

1,516 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/71fd298e83023e51e98e7a8c3d5342890b87a632

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, background): “Anatomical analysis in rodents and nonhuman primates suggests that the midbrain and striatal components of the mesocorticolimbic DA system are connected in a spiraling manner (Haber et al., 2000; Ikemoto, 2007).”
Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli (2009, methodology): “Ikemoto S (2007) Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.”
Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. (2008, positive): “To test the hypothesis that the serial cascade of striato-nigrostriatal connectivity (Haber et al., 2000; Ikemoto, 2007 ) underlies this progressively greater control over well-established cocaineseekingbehaviorbytheDLstriatum(Itoetal.,2002;Vanderschuren et al., 2005), we have used an intrastriatal”
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. (2009, background): “Individual VTA DA neurons project to one of many targets (Ikemoto 2007), and DA neurons with different targets have different physiological properties (Margolis et al., 2006, 2008; Ford et al., 2006) and may be activated at different times by different stimuli (Schultz 2007), including aversive…”
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction (2008, background): “The observations of Haber et al. (2000) in primates and, more recently, Ikemoto (2007) in rats provide a possible neuroanatomical basis.”
An Evolutionary Framework to Understand Foraging, Wanting, and Desire: The Neuropsychology of the SEEKING System (2012, background): “In contrast, the more recently evolved, more rostral and lateral dorsal striatal systems mediate habit formation, and the corresponding nigrostratal dopamine systems are much less capable of promoting reward effects, a pattern that is seen in the ventral tegmental area itself (Ikemoto, 2007).”
‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders (2009, background): “The mesolimbic dopamine projection arises from neurons in the midbrain ventral tegmental area that project up to the nucleus accumbens in the forebrain [102].”
Prediction-error in the context of real social relationships modulates reward system activity (2012, background): “…such as the ventromedial prefrontal cortex (vmPFC), which in turn provide a representational basis for both the incentive qualia of external stimuli and their reliability as a source of reward (Depue and MorroneStrupinsky, 2005; Ikemoto, 2007; van den Bos et al., 2007; see also Kahnt et al., 2010).”
Reward and aversion in a heterogeneous midbrain dopamine system (2013, background): “VTA DA neurons projecting to NAc can be subdivided based on their specific projection target (i.e. core versus medial shell versus lateral shell) and these differences may be behaviorally important (Ikemoto, 2007; Lammel et al., 2008, 2011, 2012).”
The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis (2011, background): “…striatopallidal system (Heimer et al., 1995), along with the NAcc, and largely receives input from the STR and NAcc and projects to regions outside the basal ganglia circuit, including limbic areas in the hypothalamus and the VTA (Haber et al., 1985; Groenewegen et al., 1993; Ikemoto, 2007).”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, positive): “The DA projection to the NAc also contributes to the rewards associated with drugs of abuse (Koob, 1992; Wise, 2004; Ikemoto, 2007), and plasticity in this system is strongly implicated in addictive disorders that involve compulsive drug-seeking (Wolf et al, 2004; Zweifel et al, 2008).”
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli (2011, background): “…may correspond to a transition from limbic and prefrontal cortical control over goal-directed behavior to dorsostriatal control as drug intake becomes compulsive (Haber et al., 2000; Kalivas and Volkow, 2005; Everitt and Robbins, 2005; Everitt et al., 2008; Hyman et al., 2006; Ikemoto, 2007).”
Whole-brain mapping of direct inputs to midbrain dopamine neurons. (2012, positive): “Note that the IF, PBP, PFR, PIF, PN and RLi constitute the VTA or A10 (Ikemoto, 2007).”