Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli

By F. Brischoux, Subhojit Chakraborty, D. Brierley, Mark A. Ungless. Proceedings of the National Academy of Sciences of the United States of America, 2009

793 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c48670f4489a1079da7ebb0fa7f86b1e56d789cd

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Citations in the corpus

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors (2018, background): “Motivationally salient stimuli modify dopamine neuron firing and downstream NAc activity (9, 29, 30).”
Whole-brain mapping of direct inputs to midbrain dopamine neurons. (2012, positive): “For example, several studies have suggested that dopamine neurons are activated by noxious stimuli (Brischoux et al., 2009; Joshua et al., 2008; Redgrave and Gurney, 2006).”
Reward and aversion in a heterogeneous midbrain dopamine system (2013, background): “However, subsequently the same group reported that DA neurons localized in the medioventral VTA were excited at the onset of aversive stimuli (Brischoux et al., 2009).”
Natural neural projection dynamics underlying social behavior. (2014, positive): “The VTA is a heterogeneous region comprised of diverse cell types which may play distinct roles in modulating reward and aversion based on connectivity to different upstream and downstream structures (Brischoux et al., 2009; Budygin et al., 2012; Chaudhury et al., 2013; Kalivas and Nakamura, 1999; L”
Dopamine neurons encoding long-term memory of object value for habitual behavior (2015, neutral): “Recent studies suggest that DA neurons are heterogeneous in terms of their functions (Brischoux et al., 2009; Lerner et al., 2015; Matsumoto and Hikosaka, 2009).”
Neuronal Reward and Decision Signals: From Theories to Data. (2015, methodology): “Five neurons close to juxtacellularly labeled ventral tegmental area (VTA) dopamine neurons were activated by footshocks (64), similar to the effects of airpuffs and footshocks on non-dopamine neurons in the area (102, 582).”
GABA Neurons of the VTA Drive Conditioned Place Aversion (2012, background): “It will also be important to identify the molecular learning mechanisms engaged by inhibition of DA neurons and parse the contribution of the neurons that are activated by the footshock (Brischoux et al., 2009) and other aversive stimuli (Bromberg-Martin et al., 2010a, 2010b).”
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli (2011, positive): “In agreement with previous results (Lammel et al., 2008) we found that retrogradely labeled neurons that project to the mPFC and medial shell of the NAc are mainly located in the medial posterior VTA, medial paranigral nucleus and adjacent medial aspects of the PBP nucleus (Figure 1B).”
Multiphasic Temporal Dynamics in Responses of Midbrain Dopamine Neurons to Appetitive and Aversive Stimuli (2013, background): “There have been previous reports of “rebound” activation, but these were linked to the sudden offset of relatively long duration aversive stimuli (Brischoux et al., 2009; Mileykovskiy and Morales, 2011; Wang and Tsien, 2011).”
Updating dopamine reward signals (2013, background): “Whereas interest in dopamine reward responses has overshadowed the long known aversive responses, some current work addresses punishment in identifiable groups of dopamine neurons without assessing their incidence relative to reward responsive neurons [32,42].”
Activation of VTA GABA neurons disrupts reward consumption (2012, positive): “…and identified DA neurons have demonstrated that presentation of aversive stimuli or predictive cues can transiently excite or inhibit DA neuronal activity (Brischoux et al., 2009; Matsumoto and Hikosaka, 2009; Mileykovskiy and Morales, 2011; Mirenowicz and Schultz, 1996; Zweifel et al., 2011).”
AMYGDALA MICROCIRCUITS CONTROLLING LEARNED FEAR (2014, background): “Since aversive learning activates neurons in the ventral tegmental area and locus coeruleus (Brischoux et al., 2009; Chiang and Aston- Jones, 1993), which respectively provide DA and NE inputs to LA, it is conceivable that these neuromodulators lead to disinhibition of principal cells, thereby…”
Dopamine in motivational control: rewarding, aversive, and alerting (2010, background): “Adapted with permission from Brischoux et al. (2009).”