The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.

By T. Jhou, H. Fields, Mark G. Baxter, Clifford B. Saper, P. Holland. Neuron, 2009

654 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dedd74b1b4613d9aee606dbbde7f6b99e830fc78

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Citations in the corpus

Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “In addition, LHb activity inhibits reward-related mesoaccumbens dopamine-containing neurons through an indirect pathway involving the rostromedial tegmental nucleus (RMTg) (Jhou et al., 2009).”
Prefrontal control of fear: more than just extinction (2010, background): “During renewal of fear, the excitatory drive emanating from mPFC would converge with amygdala projections to the periaqueductal grey, to produce defensive responses, while at the same time suppressing approach behaviors, via the midbrain dopaminergic system [50].”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, positive): “…of reward (Matsumoto and Hikosaka, 2007), has projections to the VTA and RMTg (Herkenham and Nauta, 1979; Araki et al, 1988; Bell et al, 2007; Jhou et al, 2009b; Kaufling et al, 2009), and mediates a nearly ubiquitous inhibitory influence on DA cell activity (Ji and Shepard, 2007; Matsumoto…”
Activation of VTA GABA neurons disrupts reward consumption (2012, neutral): “In vivo, DA neurons are thought to be tonically inhibited by GABA neurons within the VTA and the Rostromedial Tegmental Nucleus, (Jhou et al., 2009; Johnson and North, 1992b).”
Pro v Con Reviews: Is Food Addictive? (2012, background): “Moreover, neurons in the rostromedial tegmental nucleus, which receive a major input from the lateral habenula, project to VTA DA neurons and are activated after food deprivation (158).”
Neuronal Reward and Decision Signals: From Theories to Data. (2015, background): “The habenula exerts strong and exclusively inhibitory influences on dopamine neurons (95, 250, 344) via GABAergic neurons in the rostromedial reticular nucleus (226, 249).”
How Prediction Errors Shape Perception, Attention, and Motivation (2012, background): “, a dip in response to a punishing event, could be driven by lateral habenula neurons that respond to aversive events and project to the VTA GABAergic neurons (Jhou et al., 2009).”
Dopamine in motivational control: rewarding, aversive, and alerting (2010, background): “Notably, RMTg neurons have response properties similar to LHb neurons, encode motivational value, and have a heavy inhibitory projection to dopaminergic midbrain (Jhou et al., 2009a).”
Multiphasic Temporal Dynamics in Responses of Midbrain Dopamine Neurons to Appetitive and Aversive Stimuli (2013, methodology): “Very similar activations to aversive air puff have been seen previously in primate dopamine neurons (Joshua et al., 2008; Matsumoto and Hikosaka, 2009), as well as neurons of lateral habenula (Matsumoto and Hikosaka, 2008).”