Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells

By R. Rossignol, R. Gilkerson, R. Aggeler, K. Yamagata, S. Remington, R. Capaldi. Cancer Research, 2004

851 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/71e571d307f7288674579e3e017f8492e87924a8

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Citations in the corpus

Metabolic regulation of mitochondrial dynamics (2016, background): “An analogous study with human cells suggested that mitochondria elongate during growth in galactose media, which forces cells to rely more heavily on OXPHOS for ATP production (Rossignol et al., 2004).”
SLP‐2 is required for stress‐induced mitochondrial hyperfusion (2009, neutral): “Mitochondrial elongation has also been reported in cultured cells enforced to produce ATP through OXPHOS for several days (Rossignol et al , 2004).”
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. (2007, background): “Mitochondria of HeLa cells, as well, have been shown to adapt their respiration capacity to meet their energy demands (35).”
Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators (2009, background): “In addition, HeLa cells grown in galactose show elevated mitochondrial respiration rate and increased synthesis of mitochondrial proteins, as compared to those grown in glucose (25).”
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis (2008, background): “This substitution decreases the generation of ATP from glycolysis, forcing cells to increase respiration (Rossignol et al., 2004; Warburg et al., 1967).”
Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants. (2007, methodology): “In order to develop a cell model that more faithfully reports mitochondrial physiology, we forced anaerobically poised HepG2 cells to use OXPHOS by replacing the glucose in the media with galactose and glutamine as the only oxidizable substrates (Rossignol et al., 2004).”
Reductive carboxylation supports growth in tumor cells with defective mitochondria (2011, background): “4a ), a condition that forces cells to use mitochondrial metabolism to generate AT”
Posttranscriptional control of T cell effector function by aerobic glycolysis. (2013, positive): “Consistent with previously published observations in other cell types (Bustamente et al., 1977; Gohil et al., 2010; Le Goffe et al., 1999; Rossignol et al., 2004; Weinberg et al., 2010), these results indicate that galactose is not as efficiently metabolized as glucose in the glycolysis pathway—or…”
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation (2011, background): “Precedent for such energy source-induced mitochondrial morphological change was established on the observation that cells grown with galactose/glutamine instead of glucose resulted in more interconnected mitochondria with increased cristae (23).”