Posttranscriptional control of T cell effector function by aerobic glycolysis.

By Chih-Hao Chang, Jonathan D. Curtis, Leonard Maggi, B. Faubert, A. Villarino, David O’Sullivan, S. C. Huang, G. V. D. van der Windt, J. Blagih, J. Qiu and 4 more. Cell, 2013

2,083 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/589cec0fc76ff1ac7cc7b633f84ea431e6dd79f6

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In Immunology

Citations in the corpus

T cell metabolism drives immunity (2015, background): “Although aerobic glycolysis is less efficient than OXPHOS at yielding an abundance of ATP per molecule of glucose, aerobic glycolysis can generate metabolic intermediates important for cell growth and proliferation, and provides a way to maintain redox balance (NAD+/NADH) in the cell (Fig.”
Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism (2016, background): “Our findings do not support a translational mechanism of aerobic glycolysis in IFN-γ production (12), as LDHA promotes IFN-γ expression independent of its 3′UTR.”
The Warburg Effect: How Does it Benefit Cancer Cells? (2016, background): “Other studies have identified additional possible signaling mechanisms [23,50].”
Metabolic control of cell death (2014, background): “Under limitedG3Pavailability, GAPDHbinds specificmRNAs, such as that coding for interferon-g, and inhibits their translation (142).”
Targeting PI3K/Akt signal transduction for cancer therapy (2021, background): “Activated PI3K/Akt signaling promotes the uptake of glucose and amino acids by CD8+ T cells for energy-demanding cellular processes, such as proliferation and cytokine synthesis and secretion.(186) Moreover, research has shown that Akt inhibition effectively enhances memory T cell differentiation in”
Bioenergetic insufficiencies due to metabolic alterations regulated by PD-1 are an early driver of CD8+ T cell exhaustion (2016, background): “In addition, switching to glycolysis is directly linked to increased effector function (Chang et al., 2013; Ho et al., 2015).”
Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013, background): “ATP synthase, can block the expression of early activation markers after TCR ligation and blunts subsequent T cell proliferation (27), suggesting that the naïve-to-effector transition requires either de novo production of ATP by mitochondria or specific signals generated during mitochondrial”
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation (2018, positive): “The blockade of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA by the use of siRNA promotes a reduction of INF-γ in lymphocytes [136].”
T Cell Dysfunction in Cancer (2018, background): “Whereas naive T cells largely rely on oxidative phosphorylation (OXPHOS), they switch to the use of aerobic glycolysis upon antigen stimulation, to generate the required ATP (Chang et al., 2013; Pearce and Pearce, 2013).”
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016, background): “Depletion of glucosemay decrease production of interferon (IFN)-g (Chang et al., 2013) and modulate the differentiation of regulatory T cells (De Rosa et al.”
Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions (2014, background): “Remarkably, the glycolytic metabolism of Th1 cells dramatically influences their functionality, as evidenced by the fact that inhibition of glycolysis severely suppresses the secretion of IFNγ (6, 10).”