miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis.

By W. Deng, Haifan Lin. Developmental Cell, 2002

886 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/71d95b76a18003a754d82cf621f03e64f8cdddcc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Gregory J. Hannon
2. Hiroyuki Sasaki
3. R. Martienssen
4. D. Bourc’his
5. T. Bestor
6. Michael Q. Zhang
7. Thomas Tuschl
8. Eugene Berezikov

In Molecular Biology

1. Gregory J. Hannon
2. Thomas Tuschl
3. Frank J. Slack
4. Alexei Aravin
5. R. Martienssen
6. Hiroyuki Sasaki
7. David P. Bartel
8. Ravi Sachidanandam

In Plant Science

1. Gregory J. Hannon
2. Alexei Aravin
3. R. Martienssen
4. Dubravka Pezic
5. Ravi Sachidanandam
6. Thomas Tuschl
7. Hiroyuki Sasaki
8. D. Bourc’his

Citations in the corpus

• Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. (2002, background): “, and development (Zou et al., 1998; Sharma et al., 2001; Deng and Lin, 2002; in D. melanogaster (Caplen et al., 2001; Elbashir et al., 2002).”
• Spermatogenesis in fish. (2010, background): “and apoptosis occurs at the spermatocyte stage (Deng and Lin, 2002).”
• The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. (2002, background): “However, it is detected in male gonads upon initiation of spermatogenesis two weeks after birth, when it is expressed in spermatocytes and spermatids (Kuramochi-Miyagawa et al. 2001; Deng and Lin 2002).”
• Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. (2006, background): “In the mouse, all three members of the Piwi/prg AGO family, Miwi (Deng and Lin, 2002), Mili (Kuramochi-Miyagawa et al., 2004), and Miwi2 (G.J. Hannon, personal communication) are required for male fertility.”
• The role of RNA interference in heterochromatic silencing (2004, background): “Finally, two out of nine Ago homologues in mice have been knocked out, and both mutants show spermatogenesis defects and male sterilit”
• A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. (2007, background): “In mammals, miwi and mili knockout animals show defects specifically in male germ cells, consistent with their testis-specific expression (Deng and Lin, 2002; Kuramochi-Miyagawa et al., 2004).”
• Mili, a mammalian member of piwi family gene, is essential for spermatogenesis (2004, background): “Similarly, null mutations in HSP70-2, which is an essential factor for CDC2 kinase activity in meiosis I (Dix et al., 1996), and Cyclin A1 cause apparent structural abnormalities of the male germ cells by late prophase (Liu et al., 1998).”