Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

By Dos D. Sarbassov, D. Guertin, Siraj M. Ali, David M. Sabatini. Science, 2005

5,749 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/719d66e16db86cdadcdefb101144d1861e3cb0e3

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Citations in the corpus

PI3K/Akt: getting it right matters (2008, background): “mTORC2 directly phosphorylates the HM site in vitro and enhances subsequent phosphorylation of Akt by PDK1 (Sarbassov et al., 2005).”
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. (2007, methodology): “shRNA-encoding plasmids were co-transfected with the Delta VPR envelope and CMV VSV-G packaging plasmids into actively growing HEK-293T using FuGENE 6 transfection reagent as previously described (Ali and Sabatini, 2005; Sarbassov et al., 2005).”
ROS and ROS-Mediated Cellular Signaling (2016, background): “Afterwards, the activated PI3K catalyzes the synthesis of phosphatidylinositol 3,4,5-triphosphate (PIP3), from phosphatidylinositol 4,5-bisphosphate (PIP2) [88].”
Defining the role of mTOR in cancer. (2007, background): “…10 years, scientists used rapamycin to uncover mTOR-dependent processes showing that mTOR regulates cell growth by controlling mRNA translation, ribosome biogenesis, autophagy, and metabolism (Figure 1A) (reviewed in Guertin and Sabatini, 2005; Sarbassov et al., 2005a; Wullschleger et al., 2006).”
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. (2007, background): “Phosphorylation of this second site is regulated by the TORC-2 protein complex (SIN1-mLST8-rictor-mTOR) (Jacinto et al., 2006; Sarbassov et al., 2005), although whether via direct phosphorylation or indirectly, for example by modulating the stability of the phosphate at this site, remains to be esta”
The Molecular Bases of Training Adaptation (2007, background): “added to existing myofibres or combine and form new contractile filaments, each providing additional contractile machinery with which to generate force (Bolster et al. 2003a; Rennie et al. 2004; Sartorelli and Fulco 2004).”
Leveraging molecular structure and bioactivity with chemical language models for de novo drug design (2023, background): “In response to growth factor receptor and PI3K activation, AKT is phosphorylated on Ser473 by the Rictor-mTOR complex 62 .”
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development (2013, background): “We also studied the phosphorylation of protein kinase B (AKT) at S505 (p-AKT, equivalent to S473 in mammalian AKT) by the rapamycin-insensitive TORC2 complex (26).”