PI3K/Akt: getting it right matters

By T. Franke. Oncogene, 2008

724 citations recorded by the source corpus.

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/89df118474a55364ca52da9f912f90d3a43d3188

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In Molecular Biology

1. Nicholas F. Lahens
2. John B. Hogenesch
3. Michael Hughes

Citations in the corpus

• A circadian gene expression atlas in mammals: Implications for biology and medicine (2014, background): “IGF1 is one of the most potent natural activators of the PIK3-AKT-MTOR pathway, which stimulates growth, inhibits apoptosis, and has a well-known role in cancer (21).”