PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.

By J. Brognard, E. Sierecki, Tianyan Gao, A. Newton. Molecules and Cells, 2007

610 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c67e9ab875cf651850bca2497bc02333ee2bd8b2

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Citations in the corpus

Tenets of PTEN tumor suppression. (2008, background): “pho-Ser473 on AKT (Brognard et al., 2007; Gao et al., 2005).”
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. (2008, background): “Akt can also be regulated by dephosphorylation, and PP2a (202) and PHLPP (33) have been reported to be important phosphatases regulating Akt phosphorylation.”
PI3K-PKB/Akt pathway. (2012, background): “With the discovery of the potent contribution of PI3K and PKB/Akt activation to tumorigenesis, intense research into the regulation of this pathway led to the discovery of the negative regulators, the protein phosphatase 2 (PP2A), phosphatase and tensin homolog (PTEN), and the PH-domain leucine-rich”
PI3K/Akt: getting it right matters (2008, background): “, 2007), Src (Jiang and Qiu, 2003) and both known isoforms of the PH domain leucine-rich repeat protein phosphatase family (PHLPP) (Gao et al., 2005; Brognard et al., 2007).”
AKT/PKB signaling: navigating downstream. (2007, positive): “A recent study on the role of two Akt-S473 phosphatases, PHLPP1 and PHLPP2, which differentially regulate the three Akt isoforms, has emphasized the extent to which Akt substrates are isoform specific (Brognard et al., 2007).”
Defining the role of mTOR in cancer. (2007, background): “The recently described PHLPP phosphatases (PHLPP1 and PHLPP2) counteract mTORC2 by dephosphorylating AKT at S473 (Brognard et al., 2007; Gao et al., 2005).”
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer (2018, neutral): “Consistent with previous results 47,48 , overexpression of PHLPP2 (Fig.”
FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt (2009, neutral): “The Ser473 of Akt is specifically phosphorylated by mTORC2 and dephosphorylated by PHLPP phosphatases (PHLPP1 and PHLPP2) (Brognard et al., 2007; Gao et al., 2005; Sarbassov et al., 2005).”
Serine/threonine phosphatases: mechanism through structure. (2009, background): “PHLPP and PHLPP2 are thought to promote apoptosis and suppress tumor growth through dephosphorylation of distinct Akt isoforms (Brognard et al., 2007; Gao et al., 2005).”
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases (2014, background): “All three isoforms of Akt, Akt1, Akt2, and Akt3, phosphorylate GSK3β, but only Akt 2 phosphorylated GSK3α (Brognard et al., 2007).”
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “Once localized at the PM, AKT is phosphorylated at T308 and S473.”