Cutting Edge: TREM-2 Attenuates Macrophage Activation1
By Isaiah R. Turnbull, S. Gilfillan, M. Cella, T. Aoshi, Mark Miller, L. Piccio, M. Hernandez, M. Colonna. Journal of Immunology, 2006
681 citations recorded by the source corpus.
Subfields: Hematology, Immunology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/71857f3bab740cedb56b8e7abdc0a6b1990367b1
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Citations in the corpus
- A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, neutral): “For the Trem2 experiments, Trem2 / mice were generated as previously described (Turnbull et al., 2006); 5XFAD mice were purchased from the Jackson Laboratory (MMRRC) and crossed to Trem2 / mice to generate Trem2 5XFAD and Trem2 / 5XFADmice.”
- The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases (2017, methodology): “…Mouse: miR-155 / The Jackson Laboratory JAX: 007745 Mouse: Apoefl/fl Wagner et al., 2015 N/A Mouse: APP-PS1 Radde et al., 2006 N/A Mouse: Trem2 / Turnbull et al., 2006 N/A Mouse: Cx3cr1CreERT2 The Jackson Laboratory JAX: 021160 Mouse: SOD1G93A The Jackson Laboratory JAX:…”
- TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model (2015, positive): “significant more TNF-α than WT microglia in response to LPS, consistent with previous demonstrations that TREM2 attenuates cytokine responses to certain TLR ligands (Hamerman et al., 2006; Turnbull et al., 2006).”
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques (2016, neutral): “Trem2−/− mice were previously described (Turnbull et al., 2006).”
- Microglial physiology: unique stimuli, specialized responses. (2009, background): “Recent studies show that deletion of TREM2 or of DAP12 from macrophages leads to identical phenotypes (namely, enhanced inflammatory cytokine production) when challenged with TLR agonists (73).”
- TYROBP in Alzheimer’s Disease (2015, background): “Additional studies have demonstrated that the transmembrane receptor TREM2 mediated the inhibitory effects of TYROBP on TLR responses in macrophages [55, 56].”