TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
By Yaming Wang, Tyler K. Ulland, Jason D. Ulrich, Wilbur M Song, J. Tzaferis, Justin T. Hole, Peng Yuan, Thomas E Mahan, Yang Shi, S. Gilfillan and 6 more. Journal of Experimental Medicine, 2016
734 citations recorded by the source corpus.
Wang et al. report that TREM2 protects mice from Alzheimer's disease by enabling resident microglia to insulate and alter Aβ plaque structure, thereby limiting neuritic damage.
Subfields: Immunology, Neurology
View Paper: https://www.semanticscholar.org/paper/2230bd8f6bd57c232850ce4952473de6f833134f
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- D. Holtzman
- O. Butovsky
- Morgan Sheng
- Hans Lassmann
- M. Colonna
- M. Schwartz
- Zhiping Weng
- Howard L. Weiner
In Neurology
- D. Holtzman
- Hans Lassmann
- M. Colonna
- M. Schwartz
- Christian Haass
- Howard L. Weiner
- O. Butovsky
- J. Long
Citations in the corpus
- A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, positive): “…of systemic immunity, recruited monocytes, and tissue-resident microglia to ADonset and disease progression (Baruch et al., 2016; Deardorff andGrossberg, 2017; Guillot-Sestier et al., 2015; Jay et al., 2015; Koronyo et al., 2015; Lai andMcLaurin, 2012; Simard et al., 2006; Wang et al., 2016).”
- Inflammation as a central mechanism in Alzheimer's disease (2018, background): “[151] Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, et al.”
- Microglia in Alzheimer’s disease (2018, background): “A progressive neurodegenerative disorder afflicting mainly the elderly, AD is the most common cause of dementia and a leading cause of death in the United States (James et al., 2014; Weuve et al., 2014).”
- The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases (2017, background): “, 2017), although a previous study (Wang et al., 2016) found that Apoe expression in 5XFADmice wasmoderately lower than inWTmice.”