Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

By M. Sanjuán, C. Dillon, S. Tait, S. Moshiach, F. Dorsey, Samuel A. Connell, M. Komatsu, Keiji Tanaka, J. Cleveland, S. Withoff and 1 more. Nature, 2007

1,345 citations recorded by the source corpus.

Subfields: Endocrinology, Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/718321fb1476b27b41bfc1422e0dd674b13eec46

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Citations in the corpus

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells (2011, methodology): “Recently, LC3-associated phagocytosis (LAP) was identified as a phenomenon distinct from classical autophagy (16): In macrophages that engulf particles containing toll-like receptor (TLR) ligands, proteins associated with the autophagy machinery, such as Beclin1, VPS34, and LC3II, are rapidly recrui”
Mitochondria supply membranes for autophagosome biogenesis during starvation (2010, background): “, 2006), LC3 can also be recruited to membranes derived from the plasma membrane (Sanjuan et al., 2007).”
Autophagy, Immunity, and Microbial Adaptations (2009, background): “…frontier, especially since there have been reports of the inability to detect macroautophagy downstream of TLR stimulation (Saitoh et al., 2008) and discrepancies in adaptor usage downstream of certain PRRs in the context of autophagy (Delgado et al., 2008; Sanjuan et al., 2007; Xu et al., 2007).”
Autophagy in immunity and inflammation (2011, background): “Autophagy proteins are required for the fusion of phagosomes that contain Toll-like receptor (TLR)-ligand-enveloped particles with lysosomes in macrophages 31 , and for the fusion of phagosomes that contain TLR-agonist-associated apoptotic cell antigens with lysosomes in dendritic cells during MHC c”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “TLR signaling in macrophages links the autophagic pathway to phagocytosis (179).”
Molecular characterization of LC3-associated phagocytosis (LAP) reveals distinct roles for Rubicon, NOX2, and autophagy proteins (2015, positive): “Whereas the autophagosome is a double-membrane structure, the LAP-engaged phagosome (LAPosome) is composed of a single membrane 5,8,11 .”
Cell Death Signaling. (2015, background): “Recent studies have shown that components of the autophagy pathway can be recruited to phagosomes that have engulfed organisms or cells, facilitating the degradation of the phagocytosed cargo (Sanjuan et al. 2007; Martinez et al. 2011).”
Autophagy in inflammation, infection, and immunometabolism (2021, background): “The prototypical noncanonical autophagy (Fugure 1B) are LC3-associated phagocytosis (LAP) and its variations such as LC3-associated endocytosis (LANDO) (Sanjuan et al., 2007), which use only portion of the autophagy factors and operate on single membrane vesicles derived from plasma membrane, i.e., ”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “Once engulfed, entotic cells are often eliminated by a RCD subroutine that occurs independently of BCL2 proteins and caspases [694, 704], but relies (at least in part) on a specific autophagy-related process commonly known as LC3-associated phagocytosis (LAP) [509, 705, 706].”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “ple, toll-like receptor (TLR)-mediated stimulation in LC3-associated phagocytosis.(182,183) Importantly, LC3 is involved in secretory trafficking as it has been associated with secretory granules in mast cells(184) and PC12 hormone-secreting cells.”