Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

By D. Rachmilewitz, K. Katakura, F. Karmeli, Tomoko Hayashi, C. Reinus, B. Rudensky, Shizuo Akira, K. Takeda, Jongdae Lee, K. Takabayashi and 1 more. Gastroenterology, 2004

939 citations recorded by the source corpus.

Subfields: Food Science, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/70d9e80ecc568444ede6a089606484244b233733

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Citations in the corpus

The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept) (2011, background): “The anti-inflammatory effect of genomic DNA from VSL#3 bacteria was also confirmed in an in vivo murine study, which demonstrated that TLR9 signalling was essential in mediating this anti-inflammatory effect ( Rachmilewitz et al. 2004 ).”
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function (2010, background): “A similar reduction in DSS-induced colitis was observed following oral or systemic administration of the TLR9 ligand CpG OD”
Probiotics and immunity (2009, background): “VSL#3 also signifi cantly inhibited the development of DSS-induced colitis and had remarkable therapeutic effects in established colitis.(113) These effects were shown to be due to probiotic DNA, which when given orally could inhibit disease activity and improve histologic scores to a similar extent”
Immunomodulatory functions of type I interferons (2012, background): “Over the last few years, data from our laboratory and others have shown that the systemic administration of TLR9 ligands reduces the severity of colonic injury and inflammation in models of experimental coliti”
Genes and Molecules of Lactobacilli Supporting Probiotic Action (2008, background): “DNA of the probiotic cocktail VSL#3 has been shown to exert a systemically induced protective effect against dextran sulfate sodium-induced colitis mediated by TLR9 (198).”
Mechanisms of probiotic actions - A review. (2010, background): “Essential for DNA effects is the Toll-like receptor 9 (TLR9) (Rachmilewitz et al., 2004).”
Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis (2006, background): “Bacterial DNA (CpG motif), which prevents and treats experimental colitis in numerous models”
TLR Signaling in the Gut in Health and Disease1 (2005, background): “1 ND 2 * Colon primary cell line (104); (negative) RNA, protein (small intestine) (100), RNA, functional in young adult mouse colon cells, mouse small IEC (48) 3 ND 4 * Colon primary cell line (104); small intestine RNA, protein (100); functional (71); protein in cell line m-ICc12, functional (16, 1”