Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

By Paula A. Desplats, He‐Jin Lee, Eun-Jin Bae, C. Patrick, E. Rockenstein, Leslie A. Crews, B. Spencer, E. Masliah, Seung-Jae Lee. Proceedings of the National Academy of Sciences of the United States of America, 2009

1,516 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/702e229b84c7eec4b3136db15bddc412e88a1d98

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. V. Lee
2. Christian Haass
3. John Q. Trojanowski
4. Leonidas Stefanis
5. A. Schapira
6. T. Miller
7. Vladimir N Uversky
8. William W. Seeley

In Neurology

1. V. Lee
2. Leonidas Stefanis
3. John Q. Trojanowski
4. Christian Haass
5. Kelvin C. Luk
6. A. Lutz
7. K. Winklhofer
8. Nicole Exner

In Physiology

1. V. Lee
2. John Q. Trojanowski
3. Leonidas Stefanis
4. Kelvin C. Luk
5. Christian Haass
6. A. Lutz
7. K. Winklhofer
8. Nicole Exner

Citations in the corpus

• The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease (2012, background): “Transmission between individuals does not seem to occur naturally, but can be induced in experimental model systems (Clavaguera et al., 2009; Desplats et al., 2009; Eisele et al., 2010; Meyer-Luehmann et al., 2006).”
• Distinct tau prion strains propagate in cells and mice and define different tauopathies (2014, background): “…(Clavaguera et al., 2009; de Calignon et al., 2012; Iba et al., 2013; Kim et al., 2010; Liu et al., 2012) as has similar work with other intracellular amyloids such as a-synuclein (Desplats et al., 2009; Luk et al., 2012) and extracellular amyloids including amyloid b (MeyerLuehmann et al., 2006).”
• A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles (2014, background): “Secretion and cell-to-cell transfer of a-synuclein has been shown both in cells and in vivo (Lee et al, 2004, 2005, 2008a,b; Desplats et al, 2009; Luk et al, 2012a,b), and exosomes constitute a proposed method of propagation (Emmanouilidou et al, 2010; Kong et al, 2014; Lee et al, 2014).”
• Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats (2014, background): “Further experimental studies have shown that Lewy pathology can indeed propagate from one cell to another, not only in cultured cells in vitro, but also in brains of animal models of PD [11, 15, 27, 33].”
• Colonic bacterial composition in Parkinson's disease (2015, background): “, increase in proinflammatory bacteria).(42,43) Environmental factors associated with PD (age, BMI, medication use, and PD duration) might explain differences between our PD and HC subjects.”
• α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. (2011, neutral): “Furthermore, this transplantation site differs from the sites of injection in clinical grafting studies and is not a brain region strongly affected by PD (26).”
• Exosomal cell-to-cell transmission of alpha synuclein oligomers (2012, background): “demonstrated that αsyn can be directly transmitted from neuronal cells overexpressing αsyn to transplanted embryonic stem cells both in tissue culture and in transgenic animals [16].”