Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

By S. Holmqvist, Oldriska Chutna, Luc Bousset, Patrick Aldrin-Kirk, Wen Li, T. Björklund, Zhan-You Wang, L. Roybon, R. Melki, Jia-Yi Li. Acta Neuropathologica, 2014

844 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/01d452606c874c1b36fd14a2b6eb578a68763fcf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. T. Kam
2. John Q. Trojanowski
3. H. Ko
4. Viviana Gradinaru
5. Nikhil Panicker

In Neurology

1. John Q. Trojanowski
2. H. Ko
3. Andrew J. Saykin

Citations in the corpus

• Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. (2019, background): “In the Holmqvist study, they injected human brain lysates into mouse brain without substantial pathology (Holmqvist et al., 2014).”
• Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome (2018, background): “Changes in the composition of intestinal bacterial populations are associated with a wide array of neurological and neurodevelopmental disorders including multiple sclerosis, autism, depression, schizophrenia, and Parkinson’s disease[70-72].”
• Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease (2016, positive): “Further, injection of aSyn fibrils into the gut tissue of healthy rodents is sufficient to induce pathology within the vagus nerve and brainstem (Holmqvist et al., 2014).”
• Colonic bacterial composition in Parkinson's disease (2015, background): “, increase in proinflammatory bacteria).(42,43) Environmental factors associated with PD (age, BMI, medication use, and PD duration) might explain differences between our PD and HC subjects.”
• Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein (2015, neutral): “the brain has been demonstrated in wild-type rats (106, 107).”