A metabotropic glutamate receptor variant functions as a taste receptor

By Nirupa Chaudhari, A. Landin, S. Roper. Nature Neuroscience, 2000

596 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/6fb069e31200bcefabc7c02e266f9af0580d1634

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Citations in the corpus

The orbitofrontal cortex and beyond: from affect to decision-making. (2008, background): “Umami taste is produced by glutamate acting on a fifth taste system (Chaudhari et al., 2000; Maruyama et al., 2006; Zhao et al., 2003).”
A novel family of mammalian taste receptors. (2000, background): “In con-Elliot Adler,* Mark A. Hoon,*§ Ken L. Mueller,†§ Jayaram Chandrashekar,† Nicholas J. P. Ryba,*‡ trast, sweet, bitter, and umami taste transduction are believed to be mediated by G protein–coupled receptorand Charles S. Zuker†‡ *National Institute of Dental and Craniofacial Research (GPCR) sig”
A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. (2001, background): “How does the brain discern which of the differentof the metabotropic glutamate receptor as the umami sensor (Chaudhari et al., 2000).”
The receptors for mammalian sweet and umami taste. (2003, background): “…et al. described a truncated vari-Results and Discussion ant of the metabotropic glutamate receptor-4 (mGluR4t) and suggested that it functions as the umami taste re-Generation of T1R1, T1R2, and T1R3 KO Mice Expression of T1R receptors defines three largely non- ceptor (Chaudhari et al., 2000).”
The cell biology of taste (2010, background): “isoforms of G protein–coupled glutamate receptors expressed in taste buds (Chaudhari et al., 2000; Li et al., 2002; Nelson et al., 2002; San Gabriel et al., 2009).”
A family of candidate taste receptors in human and mouse (2000, unknown): “Although they have the seven-transmembrane domain structure characteristic of GPCRs, they are unrelated in sequence to both mGluR4, which detects glutamat”
Genes and ligands for odorant, vomeronasal and taste receptors (2004, background): “Transduction of umami taste is proposed to involve T1R1 combined with T1R3, but a splice variant of the mGluR4 glutamate receptor might also function as an umami recepto”
T2Rs function as bitter taste receptors. (2000, background): “To date, many putative taste receptors have been reported (Abe et al., 1993; Matsuoka et al., 1993; Ming et al., 1998; Hoon et al., 1999; Chaudhari et al., 2000).”
Mammalian G proteins and their cell type specific functions. (2005, background): “In addition, T1R3 may form homodimers that can also mediate some sweet tastes, and there is evidence that also a splice variant of the mGluR4 glutamate receptor may be involved in umami sensation (95, 96, 127, 730).”
Umami Taste Responses Are Mediated by α-Transducin and α-Gustducin (2004, background): “tion in humans, Chinese hamster ovary cells expressing taste mGluR4 responded by lowering cellular cAMP concentrations (Chaudhari et al., 2000).”
An amino-acid taste receptor (2002, background): “Recently, a mGluR4 splice variant has been reported as a candidate umami recepto”