The hormone resistin links obesity to diabetes

By C. Steppan, S. Bailey, Savitha D. Bhat, Elizabeth J Brown, Ronadip R. Banerjee, Christopher M Wright, H. Patel, R. Ahima, Mitchell A. Lazar. Nature, 2001

4,969 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/6f14db9a433a87961de4717f1191b583a6c10c98

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Citations in the corpus

Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “While mouse resistin is exclusively expressed in white adipose tissue, human resistin is mainly expressed in circulating mononuclear cells (Savage et al. 2001; Steppan et al. 2001; Patel et al. 2003).”
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, neutral): “(610), is a cytokine expressed exclusively in adipocytes in mice but is expressed predominantly in macrophages in human subjects (489).”
New drug targets for type 2 diabetes and the metabolic syndrome (2001, methodology): “4 ) were identified using PCR-differential messenger RNA display, DNA microarrays and related technique”
Increased oxidative stress in obesity and its impact on metabolic syndrome. (2004, background): “Adipocytes produce a variety of biologically active molecules (4–9), collectively known as adipocytokines or adipokines, including plasminogen activator inhibitor–1 (PAI-1) (10), TNF-α (11, 12), resistin (13, 14), leptin (15–17), and adiponectin (18–21).”
Adiponectin and adiponectin receptors. (2005, background): “Adipose tissue also participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipokines such as free fatty acid (3), adipsin (4), leptin (5), plasminogen activator inhibitor-1 (6), resistin (7), and TNF- (8).”
Adipokines: the missing link between insulin resistance and obesity. (2008, background): “[54] brought to light a gene encoding or resistin.”
Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. (2015, background): “It mediates its effects on insulin resistance by activating suppressor of cytokine signaling 3 (SOCS3) that interferes with insulin signaling (176).”
The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. (2004, background): “Finally, it must be pointed out that although the potential actions of PPARs are now known, thanks to synthetic ligands such as TZDs or fibrates, their activation in physiological and pathophysiological situations by endogenous ligands are still poorly understood.”
Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating Properties1 (2007, background): “A dipose tissue has emerged as an important endocrine organ producing a variety of secreted factors including TNF- (1), IL-6 and IL-8 (2), plasminogen-activator inhibitor type 1 (3), leptin (4), adiponectin (5, 6), resistin (7), and others.”
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? (2003, background): “In this regard, several possible candidate molecules have been suggested including tumor necrosis factor(61), leptin (62), FFAs (5,6,63), and, most recently, resistin (64).”
The role of the novel adipocyte-derived hormone adiponectin in human disease. (2003, background): “resistin has been identified as a novel adipose-specific cysteine-rich protein with a capacity to impair insulin sensitivity and glucose tolerance in murine models ( 7 ).”
Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “, 2000) and insulin resistance (Steppan et al., 2001).”
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. (2002, neutral): “(290–295), and most recently, resistin (296).”