Increased oxidative stress in obesity and its impact on metabolic syndrome.

By S. Furukawa, T. Fujita, M. Shimabukuro, M. Iwaki, Yukio Yamada, Yoshimitsu Nakajima, O. Nakayama, M. Makishima, M. Matsuda, I. Shimomura. Journal of Clinical Investigation, 2004

5,347 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/cb9e29db0b631e61cf2d1bf088c34963c3468b9b

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Citations in the corpus

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies (2015, background): “Elevated plasma FFA promote the generation of O2 - in the mitochondrial electron transport chain by inhibiting the translocation of adenine nucleotides.43 FFA stimulate the production of reactive intermediates through PKC-dependent activation of NOX in cultured vascular cells.44 Conjugated fatty aci”
Phenolic acids: Natural versatile molecules with promising therapeutic applications (2019, background): “The oxidative stress is vastly associated with the damage of organs through ROS which poorly neutralized by antioxidants leads to the inflammation and variety of metabolic disorders [130].”
Metabolic syndrome: definitions and controversies (2011, background): “Cellular oxidative stress/renin-angiotensin-aldosterone system and MetS Emerging evidence suggests that nitric oxide (NO), inflammatory and oxidative stress also play important roles in the pathophysiology of MetS hypertension and DMT2 [94,95].”
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. (2007, background): “Oxidative stress and inflammation in the adipose tissue induce an imbalance in the production of adipocyte-specific hormones and cytokines (adipokines) that contribute substantially to the development of insulin resistance and cardiovascular risk associated with obesity (6, 13, 57).”
SirT1 gain-of-function increases energy efficiency and prevents diabetes in mice (2008, neutral): “, 2007; Qiao and Shao, 2006), the hyperadiponectinemia of SirBACO mice may have heterogeneous causes, including changes in badrenergic signaling or redox potential (Fasshauer et al., 2001; Furukawa et al., 2004).”
Uric Acid: The Oxidant-Antioxidant Paradox (2008, background): “[35] An increase in the oxidant production in adipocytes is an accompanying factor and a consequence of the lipid accumulation during differentiation.[17] We have found that the inclusion of uric acid in the media during the differentiation process or short-term incubation with differentiated adipoc”
The role of FoxO in the regulation of metabolism (2008, background): “FoxO1 and adipocyte function In non-diabetic obese humans and rodents, oxidative stress markers are elevated and the expression of antioxidant enzymes is decreased, particularly in adipose tissue (Furukawa et al., 2004).”
Screening for potential new probiotic based on probiotic properties and α-glucosidase inhibitory activity (2014, background): “Several studies have demonstrated that the association of oxidative stress markers with diabetes and ROS plays an important role in the regulation of insulin resistance (Furukawa et al., 2004; Houstis, Rosen, & Lander, 2006; Urakawa et al., 2003).”
Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. (2013, background): “Similarly, the oxidative tress levels in plasma from obese mice were eleated compared to control mice [10].”
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500294-JLR200 (2005, background): “Hypertrophic adipocytes are subjected to multiple cytotoxic stressors, including endoplasmic reticulum stress, hypoxia, increased TNF-� , reactive oxygen species, and free fatty acids (1, 4, 33, 34, 44 , 45).”