Functionally significant insulin-like growth factor I receptor mutations in centenarians

By Y. Suh, G. Atzmon, Miook Cho, David Hwang, Bingrong Liu, D. Leahy, Nir Barzilai, P. Cohen. Proceedings of the National Academy of Sciences of the United States of America, 2008

730 citations recorded by the source corpus.

Subfields: Aging, Endocrinology, Diabetes and Metabolism, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/6eb0ad21fd959bc1caf6b46a3c2bb62e8e5ff700

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. R. Ricklefs
2. P. Monaghan
3. G. Lithgow
4. Rute Martins
5. W. Link
6. C. Kenyon
7. D. Nussey
8. Nicholas A. Bishop

In Endocrinology, Diabetes and Metabolism

1. C. Kenyon
2. Nir Barzilai

In Pediatrics, Perinatology and Child Health

1. P. Monaghan
2. R. Ricklefs
3. D. Nussey
4. C. Kenyon

Citations in the corpus

• FOXO3A genotype is strongly associated with human longevity (2008, background): “(38), which links functionally significant IGF-1 receptor mutations to exceptional longevity, but we have not found any published reports of association between FOXO genes and human longevity.”
• Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. (2009, background): “tations resulted in reduced IGF-I signaling in transformed lymphocytes (202).”
• The genetics of ageing (2010, background): “Mutations known to impair IGF-1 receptor function are overrepresented in a cohort of Ashkenazi Jewish centenarian”
• Neural mechanisms of ageing and cognitive decline (2010, background): “Polymorphisms in two IIS pathway genes, the IGF-1 receptor and the downstream FOXO3 transcription factor, have been associated with longevity and healthy ageing in human”
• Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates (2012, neutral): “As genetic associations have been previously reported with human longevity and aging phenotypes (Atzmon et al., 2006; Suh et al., 2008; Willcox et al., 2008; Wheeler et al., 2009), we examined whether the model could distinguish aging rates for individuals with different genetic variants.”
• The Critical Role of Metabolic Pathways in Aging (2012, background): “Furthermore, attenuated insulin/IGF-1 signaling (IIS) in invertebrates and rodents has led to extended life span (31,32), and functional IGF-1R mutations in humans have been linked to exceptional longevity (33).”
• The evolutionary ecology of senescence (2008, background): “Molecular work has identified numerous genes associated with increased longevity in humans, fruit flies and nematode worms and has pinpointed metabolic pathways that are likely to play a crucial role in driving variation in longevity and senescence patterns (Kenyon et al. 1993; Lin, Seroude & Benzer”
• Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “Others have also revealed the importance of genetic variations in the IIS pathway in long-lived individuals from Italian, Japanese, Ashkenazi Jewish, or Dutch ethnicity (Arai et al., 2001; Bonafe et al., 2003; Kojima et al., 2004; Kuningas et al., 2007; Suh et al., 2008; Pawlikowska et al., 2009).”
• Growth Hormone Receptor Deficiency is Associated With a Major Reduction in Pro-aging Signaling, Cancer and Diabetes in Humans (2011, neutral): “Our results may also provide a partial explanation for the overrepresentation of partial loss-of-function mutations in the IGF-1 receptor gene among Ashkenazi Jewish centenarians (67).”